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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Obesity is a worldwide problem that is associated with metabolic disorders. Obesity is caused by the accumulation of an abnormal amount of body fat in adipose tissue. Adipose tissue is a major metabolic organ, and it has been classified as either white adipose tissue (WAT) or brown adipose tissue (BAT). WAT and BAT are characterized by different anatomical locations, orphological structures, functions, and gene expression patterns. WAT is mainly involved in the storage and mobilization of energy in the form of triglycerides. On the other hand, BAT specializes in dissipating energy as heat through uncoupling protein-1 (UCP-1)-mediated non-shivering thermogenesis. Novel type of brown-like adipocyte within WAT called beige/brite cells was recently discovered, and this transdifferentiation process is referred to as the “browning” or “britening” of WAT. Recently, Brown fat and/or browning of WAT have been highlights as a new therapeutic target for treatment of obesity and its related metabolic disorders. Here, we describe recent advances in the study of BAT and browning of WAT, focusing on proteomic approaches.
목차
Abstract
Ⅰ. 서론
Ⅱ. 본론
Ⅲ. 결론
참고문헌
참고문헌 (40)
참고문헌 신청
Mallick P / 2010 / Proteomics: A pragmatic perspective / Nat. Biotechnol 28:695~709
Ghosh D / 2009 / “Omics” data and levels of evidence for biomarker discovery / Genomics 93:13~16
Yang W / 2008 / Proteomic approaches to the analysis of multiprotein signaling complexes / Proteomics 8:832~851
Cravatt BF / 2007 / The biological impact of mass-spectrometry-based proteomics / Nature 450:991~1000
Kim EY / 2015 / Recent advances in proteomic studies of adipose tissues and adipocytes / Int. J. Mol. Sci 16:4581~4599
Ghosh D / 2009 / “Omics” data and levels of evidence for biomarker discovery / Genomics 93:13~16
Yang W / 2008 / Proteomic approaches to the analysis of multiprotein signaling complexes / Proteomics 8:832~851
Cravatt BF / 2007 / The biological impact of mass-spectrometry-based proteomics / Nature 450:991~1000
Kim EY / 2015 / Recent advances in proteomic studies of adipose tissues and adipocytes / Int. J. Mol. Sci 16:4581~4599
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UCI(KEPA) : I410-ECN-0101-2017-594-002253310