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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 295 - 302 (8page)
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초록· 키워드
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Eosinophils are multifunctional leukocytes implicated in protection against helminth infections. Although eosinophils comprise between 1~5% of peripheral blood leukocytes, they primarily reside in the gastrointestinal tract under homeostatic conditions, and rapidly proliferate upon parasitic infection. Intestinal infection with Trichinella spiralis (T. spiralis) induces eosinophilia when the parasite enters the larval stages and larvae finally migrate to the skeletal muscle. Eosinophils are known to mediate parasite death through antibody-dependent cellular cytotoxicity. In this study, we aimed to address the functional significance of eosinophils in the intestinal phase of T. spiralis infection by analysis of immune responses in the Peyer’s patch (PP) of infected BALB/c and eosinophil-ablated ΔdblGATA mice. Trafficking of eosinophils to the PP was significantly increased, with upregulation of interleukin-5 at 14 days post infection. Eosinophil deficiency led to a significant augmentation of serum immunoglobulin (Ig) M and IgG1 antibody levels. In accordance with this, IgG1<SUP>+</SUP> B cells in the PP were substantially increased in ΔdblGATA mice compared to that in BALB/c mice. Transforming growth factor-β expression in the PP of infected ΔdblGATA mice was significantly decreased compared to that in BALB/c mice, whereas the number of T. spiralis larvae in the diaphragm was increased. Taken together, these findings indicate that eosinophils contribute to the regulation of Th2 immune responses, and protect the host from T. spiralis attempting to establish larvae in the skeletal muscle.
목차
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - 정윤재 / 2015 / Eosinophils are Required for Immune Responses Induced by Oral Immunization / Journal of Bacteriology and Virology 45 (4) : 354 ~ 363
[학술지(정기간행물)] - Rothenberg ME / 2006 / The eosinophil / Annu Rev Immunol 24 : 147 ~ 174
[학술지(정기간행물)] - Yu C / 2002 / Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo / J Exp Med 195 : 1387 ~ 1395
[학술지(정기간행물)] - Jung Y / 2014 / Roles and regulation of gastrointestinal eosinophils in immunity and disease / J Immunol 193 : 999 ~ 1005
[학술지(정기간행물)] - Rosenberg HF / 2007 / Eosinophil trafficking in allergy and asthma / J Allergy Clin Immunol 119 : 1303 ~ 1310
[학술지(정기간행물)] - Rothenberg ME / 2006 / The eosinophil / Annu Rev Immunol 24 : 147 ~ 174
[학술지(정기간행물)] - Yu C / 2002 / Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo / J Exp Med 195 : 1387 ~ 1395
[학술지(정기간행물)] - Jung Y / 2014 / Roles and regulation of gastrointestinal eosinophils in immunity and disease / J Immunol 193 : 999 ~ 1005
[학술지(정기간행물)] - Rosenberg HF / 2007 / Eosinophil trafficking in allergy and asthma / J Allergy Clin Immunol 119 : 1303 ~ 1310
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UCI(KEPA) : I410-ECN-0101-2017-475-001976750