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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 307 - 311 (5page)
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초록· 키워드
오류제보하기
Gut microbiota inhabit the host gastrointestinal (GI) tract and play roles in many aspects of metabolic and immunologic homeostasis. Understanding about gut microbiota composition in health and disease is accumulating with the advances in gene sequencing technology. Graft-versus-host disease (GVHD) is a major complication after allogenic bone marrow transplantation (allo-BMT), a gold standard clinical procedure to treat hematologic disorders such as leukemia and lymphomas. Recent studies have shown that a disturbance in the gut microbiota affects GVHD prognosis. Decrease in a compositional diversity is suggested as an independent predictor of GVHD and colonization of noncommensal Enterococcus is shown to be involved in unpleasant treatment outcomes. This article describes current understanding about allo-BMT-induced gut microbiota changes and its involvement in the incidence of GVHD. In addition, several putative therapeutic strategies to decrease GVHD-related mortality after allo-BMT are discussed.
목차
INTRODUCTION
CLOSING REMARKS
REFERENCES
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] - Jandhyala SM / 2015 / Role of the normal gut microbiota / World J Gastroenterol 21 : 8787 ~ 8803
[학술지(정기간행물)] - Manzo VE / 2015 / The human microbiome in hematopoiesis and hematologic disorders / Blood 126 : 311 ~ 318
[학술지(정기간행물)] - Jones JM / 1971 / Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras / Radiat Res 45 : 577 ~ 588
[학술지(정기간행물)] - van Bekkum DW / 1974 / Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora / J Natl Cancer Inst 52 : 401 ~ 404
[학술지(정기간행물)] - Storb R / 1983 / Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment / N Engl J Med 308 : 302 ~ 307
[학술지(정기간행물)] - Manzo VE / 2015 / The human microbiome in hematopoiesis and hematologic disorders / Blood 126 : 311 ~ 318
[학술지(정기간행물)] - Jones JM / 1971 / Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras / Radiat Res 45 : 577 ~ 588
[학술지(정기간행물)] - van Bekkum DW / 1974 / Mitigation of secondary disease of allogeneic mouse radiation chimeras by modification of the intestinal microflora / J Natl Cancer Inst 52 : 401 ~ 404
[학술지(정기간행물)] - Storb R / 1983 / Graft-versus-host disease and survival in patients with aplastic anemia treated by marrow grafts from HLA-identical siblings. Beneficial effect of a protective environment / N Engl J Med 308 : 302 ~ 307
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UCI(KEPA) : I410-ECN-0101-2017-475-001976730