지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.91 No.1
- 발행연도
- 2016.6
- 수록면
- 23 - 28 (6page)
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초록· 키워드
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Purpose: Previous studies have shown the role of Sal-like protein 4 (SALL4) as a biomarker in hepatocellular carcinoma (HCC), and some studies have shown the relationship between SALL4 and prognosis. Given the debates in study groups differences in terms of etiologic causes between Western and Asian HCC and detection methods, we attempted to verify the features of SALL4 immunoreactivity and its clinical correlation in Korean HCC patients.
Methods: Immunohistochemical staining of SALL4 of tissue microarrays (TMAs) consisting of 213 surgically resected HCC patients’ tissue were scored in a semiquantitative scoring system with immunoreactive score and the results analyzed with clinical outcome, in addition to general demographics and clinical characteristics.
Results: SALL4 immunoreactivity was expressed in 50 cases. Relevance between SALL4 and α-FP correlated significantly (P= 0.002). Also, the SALL4-positive patients had considerably higher tumor grade (P < 0.001). The survival analysis showed negative correlation with SALL4 immunoreactivity in all HCC patient groups, but SALL4 immunoreactivity in T3 and T4 HCC correlated with poor prognosis.
Conclusion: Here, we found that positive immunostaining of SALL4 is correlated with poor patient survival outcome in large and undifferentiated Korean HCC. SALL4 expression showed close relationship with clinical outcomes of HCCs in Korean patients.
Methods: Immunohistochemical staining of SALL4 of tissue microarrays (TMAs) consisting of 213 surgically resected HCC patients’ tissue were scored in a semiquantitative scoring system with immunoreactive score and the results analyzed with clinical outcome, in addition to general demographics and clinical characteristics.
Results: SALL4 immunoreactivity was expressed in 50 cases. Relevance between SALL4 and α-FP correlated significantly (P= 0.002). Also, the SALL4-positive patients had considerably higher tumor grade (P < 0.001). The survival analysis showed negative correlation with SALL4 immunoreactivity in all HCC patient groups, but SALL4 immunoreactivity in T3 and T4 HCC correlated with poor prognosis.
Conclusion: Here, we found that positive immunostaining of SALL4 is correlated with poor patient survival outcome in large and undifferentiated Korean HCC. SALL4 expression showed close relationship with clinical outcomes of HCCs in Korean patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (18)
참고문헌 신청
[학술지(정기간행물)] - Parkin DM. / 2005 / Global cancer statistics, 2002 / CA Cancer J Clin 55 : 74 ~ 108
[학술지(정기간행물)] - Llovet JM. / 2008 / Molecular targeted therapies in hepatocellular carcinoma / Hepatology 48 : 1312 ~ 1327
[학술지(정기간행물)] - Bruix J. / 2011 / Management of hepatocellular carcinoma : an update / Hepatology 53 : 1020 ~ 1022
[학술지(정기간행물)] - Wurmbach E. / 2007 / Genomewide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma / Hepatology 45 : 938 ~ 947
[학술지(정기간행물)] - Llovet JM. / 2006 / A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis / Gastroenterology 131 : 1758 ~ 1767
[학술지(정기간행물)] - Llovet JM. / 2008 / Molecular targeted therapies in hepatocellular carcinoma / Hepatology 48 : 1312 ~ 1327
[학술지(정기간행물)] - Bruix J. / 2011 / Management of hepatocellular carcinoma : an update / Hepatology 53 : 1020 ~ 1022
[학술지(정기간행물)] - Wurmbach E. / 2007 / Genomewide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma / Hepatology 45 : 938 ~ 947
[학술지(정기간행물)] - Llovet JM. / 2006 / A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis / Gastroenterology 131 : 1758 ~ 1767
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UCI(KEPA) : I410-ECN-0101-2017-514-001019605