Antifilarial and Antibiotic Activities of Methanolic Extracts of Melaleuca cajuputi Flowers

Nazeh M. Al-Abd; Zurainee Mohamed Nor; Marzida Mansor; MS Hasan; Mustafa Kassim

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자료유형: 학술저널

저자정보: Nazeh M. Al-Abd (University of Malaya) Zurainee Mohamed Nor (University of Malaya) Marzida Mansor (University of Malaya) MS Hasan (University of Malaya) Mustafa Kassim (University of Malaya)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.54 No.3

발행연도: 2016.6

수록면: 273 - 280 (8page)

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We evaluated the activity of methanolic extracts of Melaleuca cajuputi flowers against the filarial worm Brugia pahangi and its bacterial endosymbiont Wolbachia. Anti-Wolbachia activity was measured in worms and in Aedes albopictus Aa23 cells by PCR, electron microscopy, and other biological assays. In particular, microfilarial release, worm motility, and viability were determined. M. cajuputi flower extracts were found to significantly reduce Wolbachia endosymbionts in Aa23 cells, Wolbachia surface protein, and microfilarial release, as well as the viability and motility of adult worms. Anti-Wolbachia activity was further confirmed by observation of degraded and phagocytized Wolbachia in worms treated with the flower extracts. The data provided in vitro and in vivo evidence that M. cajuputi flower extracts inhibit Wolbachia, an activity that may be exploited as an alternative strategy to treat human lymphatic filariasis.

#Brugia pahangi #Wolbachia #lymphatic filariasis #Melaleuca cajuputi #natural product

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참고문헌 신청

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