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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 187 - 194 (8page)
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초록· 키워드
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Peptidoglycan in inserts and mammals is well known to improve biological functions in the host`s immune system. However, it is unclear how Peptidoglycan exerted its anti-inflammatory capacity especially in clam worm (Marphysa sanguinea). In this experiment, the anti-inflammatory and antioxidant effects of clam worm extract treated with (PCWE) peptidoglycan (Micrococcus luteus) in RAW264.7 cells were examined by measuring MDA, catalase, SOD, GSH-Px and inflammatory cytokines (nitric oxide, iNOS, interleukin-1β and tumor necrosis factor-α). PCWE significantly increased the activities of catalase, SOD and GSH-Px and decreased the level of MDA. Interestingly, PCWE induced activities of SOD and GSH-Px more than clam worm extract without peptidoglycan (CWE). In addition, PCWE decreased NO production, iNOS, COX-2, TNF-α and IL-1β better than CWE. Taken together, these results indicate that PCWE has the potential as a natural antioxidant and a therapeutic for inflammation-related diseases.
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참고문헌 (28)
참고문헌 신청
Pan, W. / 2004 / Perinerin, a novel antimicrobial peptide purified from the clamworm Perinereis aibuhitensis grube and its partial characterization / J. Biochem 135:297~304
Zhou, Q. / 2009 / Cloning and expression of a clamworm antimicrobial peptide perinerin in Pichia pastoris / Curr. Microbiol 58:384~388
Yoshimura, A. / 1999 / Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2 / J. Immunol 163:1~5
Dziarski, R. / 2000 / Interactions of CD14 with components of gram-positive bacteria / Chem. Immunol 74:83~107
Wang, J. E. / 2000 / Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model / Infect. Immun 68:3965~3970
Zhou, Q. / 2009 / Cloning and expression of a clamworm antimicrobial peptide perinerin in Pichia pastoris / Curr. Microbiol 58:384~388
Yoshimura, A. / 1999 / Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2 / J. Immunol 163:1~5
Dziarski, R. / 2000 / Interactions of CD14 with components of gram-positive bacteria / Chem. Immunol 74:83~107
Wang, J. E. / 2000 / Peptidoglycan and lipoteichoic acid from Staphylococcus aureus induce tumor necrosis factor alpha, interleukin 6 (IL-6), and IL-10 production in both T cells and monocytes in a human whole blood model / Infect. Immun 68:3965~3970
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