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Innate immune cells survey antigenic materials beneath our body surfaces and provide a front-line response to internal and external danger signals. Dendritic cells (DCs), a subset of innate immune cells, are critical sentinels that perform multiple roles in immune responses, from acting as principal modulators to priming an adaptive immune response through antigen-specific signaling. In the gut, DCs meet exogenous, non-harmful food antigens as well as vast commensal microbes under steady-state conditions. In other instances, they must combat pathogenic microbes to prevent infections. In this review, we focus on the function of intestinal DCs in maintaining intestinal immune homeostasis. Specifically, we describe how intestinal DCs affect IgA production from B cells and influence the generation of unique subsets of T cell.
목차
INTRODUCTION
INTESTINAL DCs AND MACROPHAGE SUBSETS
REGULATORY T CELLS AND INTESTINAL DCs
T CELL DIFFERENTIATION AND INTESTINAL DCs
SECRETORY IgA AND INTESTINAL DCs
CONCLUSION AND FUTURE PERSPECTIVE
REFERENCES
참고문헌 (53)
참고문헌 신청
1. [단행본] - Murphy, K. / 2012 / Janeway's immunobiology / Garland Science : 466 ~ 468
2. [학술지(정기간행물)] - Ciorba, M. A. / 2012 / Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner / Gut 61 : 829 ~ 838
3. [학술지(정기간행물)] - Fukuda, S. / 2011 / Bifidobacteria can protect from enteropathogenic infection through production of acetate / Nature 469 : 543 ~ 547
4. [학술지(정기간행물)] - Pickard, J. M. / 2014 / Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness / Nature 514 : 638 ~ 641
5. [학술지(정기간행물)] - Denning, T. L. / 2011 / Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization / J. Immunol
2. [학술지(정기간행물)] - Ciorba, M. A. / 2012 / Lactobacillus probiotic protects intestinal epithelium from radiation injury in a TLR-2/cyclo-oxygenase-2-dependent manner / Gut 61 : 829 ~ 838
3. [학술지(정기간행물)] - Fukuda, S. / 2011 / Bifidobacteria can protect from enteropathogenic infection through production of acetate / Nature 469 : 543 ~ 547
4. [학술지(정기간행물)] - Pickard, J. M. / 2014 / Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness / Nature 514 : 638 ~ 641
5. [학술지(정기간행물)] - Denning, T. L. / 2011 / Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization / J. Immunol
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UCI(KEPA) : I410-ECN-0101-2016-511-001754517