지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 111 - 120 (10page)
이용수
초록· 키워드
오류제보하기
Dendritic cells (DCs) play a significant role in establishing self-tolerance through their ability to present self-antigens to developing T cells in the thymus. DCs are predominantly localized in the medullary region of thymus and present a broad range of self-antigens, which include tissue-restricted antigens expressed and transferred from medullary thymic epithelial cells, circulating antigens directly captured by thymic DCs through coticomedullary junction blood vessels, and peripheral tissue antigens captured and transported by peripheral tissue DCs homing to the thymus. When antigen-presenting DCs make a high affinity interaction with antigen-specific thymocytes, this interaction drives the interacting thymocytes to death, a process often referred to as negative selection, which fundamentally blocks the self-reactive thymocytes from differentiating into mature T cells. Alternatively, the interacting thymocytes differentiate into the regulatory T (Treg) cells, a distinct T cell subset with potent immune suppressive activities. The specific mechanisms by which thymic DCs differentiate Treg cells have been proposed by several laboratories. Here, we review the literatures that elucidate the contribution of thymic DCs to negative selection and Treg cell differentiation, and discusses its potential mechanisms and future directions.
목차
INTRODUCTION
SUBSET AND ORIGIN OF THYMIC DCs
ANTIGEN ACQUISITION AND PRESENTATION BY THYMIC DCs
ROLE OF THYMIC DCs IN NEGATIVE SELECTION
ROLE OF THYMIC DCs IN TREG CELL DEVELOPMENT
THE MECHANISMS BY WHICH THYMIC DCs MEDIATE TREG CELL DEVELOPMENT
CONCLUSION AND FUTURE DIRECTION
REFERENCES
참고문헌 (62)
참고문헌 신청
[학술지(정기간행물)] - Banchereau, J. / 1998 / Dendritic cells the control of immunity / Nature 392 : 245 ~ 252
[학술지(정기간행물)] - Mellman, I. / 2001 / Dendritic cells : specialized regulated antigen processing machines / Cell 106 : 255 ~ 258
[학술지(정기간행물)] - Klein, L. / 2009 / Antigen presentation in the thymus for positive selection central tolerance induction / Nat. Rev. Immunol 9 : 833 ~ 844
[학술지(정기간행물)] - Mathis, D. / 2004 / Back to central tolerance / Immunity 20 : 509 ~ 516
[학술지(정기간행물)] - Hsieh, C. S. / 2012 / Selection of regulatory T cells in the thymus / Nat. Rev. Immunol 12 : 157 ~ 167
[학술지(정기간행물)] - Mellman, I. / 2001 / Dendritic cells : specialized regulated antigen processing machines / Cell 106 : 255 ~ 258
[학술지(정기간행물)] - Klein, L. / 2009 / Antigen presentation in the thymus for positive selection central tolerance induction / Nat. Rev. Immunol 9 : 833 ~ 844
[학술지(정기간행물)] - Mathis, D. / 2004 / Back to central tolerance / Immunity 20 : 509 ~ 516
[학술지(정기간행물)] - Hsieh, C. S. / 2012 / Selection of regulatory T cells in the thymus / Nat. Rev. Immunol 12 : 157 ~ 167
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UCI(KEPA) : I410-ECN-0101-2016-511-001754633