지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.90 No.1
- 발행연도
- 2015.12
- 수록면
- 1 - 9 (9page)
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Purpose: Nodal infiltration has been one of the most important prognostic factors in breast cancer. In recent decades, risk stratification has greatly changed, and is applied in accordance with hormone receptor and human epidermal growth factor receptor 2 (HER2) status. We compared the prognostic power of tumor subtype to nodal involvement in early breast cancer.
Methods: We reviewed the medical records of 505 patients who had curative surgery for stage I or II breast cancer. We analyzed clinicopathologic factors according to tumor subtype and nodal involvement. Tumors were classified into 4 subtypes according to immunohistochemical status of estrogen receptor, progesterone receptor, HER2, and Ki67 labeling index. Disease-free survival (DFS) and overall survival were analyzed.
Results: There were 363 node-negative patients (71.9%) and 142 node-positive patients (28.1%). Luminal A, Luminal B, HER2, and triple-negative breast cancer subtypes were composed of 207 (41.0%), 147 (29.1%), 42 (8.3%), and 109 patients (21.6%), respectively. The median follow-up period was 89.5 months. Node negative-luminal A subtype showed the best prognosis with regard to 5-year DFS, and the pN1-triple negative subtype was associated with the shortest DFS (95.1% vs. 67.8%; hazard ratio, 9.554; P < 0.001). However, the node negative-triple negative subtype was associated with a worse 5-year DFS than the pN1-luminal A subtype ([86.4%; hazard ratio, 2.647; P = 0.048] vs. [93.2%; hazard ratio, 2.061; P = 0.194]).
Conclusion: Node negative-triple negative breast cancer was associated with a poorer prognosis than pN1-luminal A subtype. Tumor subtype has greater prognostic power compared to nodal status in early breast cancer.
Methods: We reviewed the medical records of 505 patients who had curative surgery for stage I or II breast cancer. We analyzed clinicopathologic factors according to tumor subtype and nodal involvement. Tumors were classified into 4 subtypes according to immunohistochemical status of estrogen receptor, progesterone receptor, HER2, and Ki67 labeling index. Disease-free survival (DFS) and overall survival were analyzed.
Results: There were 363 node-negative patients (71.9%) and 142 node-positive patients (28.1%). Luminal A, Luminal B, HER2, and triple-negative breast cancer subtypes were composed of 207 (41.0%), 147 (29.1%), 42 (8.3%), and 109 patients (21.6%), respectively. The median follow-up period was 89.5 months. Node negative-luminal A subtype showed the best prognosis with regard to 5-year DFS, and the pN1-triple negative subtype was associated with the shortest DFS (95.1% vs. 67.8%; hazard ratio, 9.554; P < 0.001). However, the node negative-triple negative subtype was associated with a worse 5-year DFS than the pN1-luminal A subtype ([86.4%; hazard ratio, 2.647; P = 0.048] vs. [93.2%; hazard ratio, 2.061; P = 0.194]).
Conclusion: Node negative-triple negative breast cancer was associated with a poorer prognosis than pN1-luminal A subtype. Tumor subtype has greater prognostic power compared to nodal status in early breast cancer.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Perou CM. / 2000 / Molecular portraits of human breast tumours / Nature 406 : 747 ~ 752
[학술지(정기간행물)] - Sorlie T. / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98 : 10869 ~ 10874
[학술지(정기간행물)] - Sorlie T. / 2003 / Repeated observation of breast tumor subtypes in independent gene expression data sets / Proc Natl Acad Sci U S A 100 : 841823 ~
[학술지(정기간행물)] - Prat A. / 2011 / Deconstructing the molecular portraits of breast cancer / Mol Oncol 5 : 5 ~ 23
[학술지(정기간행물)] - Goldhirsch A. / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24 : 2206 ~ 2223
[학술지(정기간행물)] - Sorlie T. / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98 : 10869 ~ 10874
[학술지(정기간행물)] - Sorlie T. / 2003 / Repeated observation of breast tumor subtypes in independent gene expression data sets / Proc Natl Acad Sci U S A 100 : 841823 ~
[학술지(정기간행물)] - Prat A. / 2011 / Deconstructing the molecular portraits of breast cancer / Mol Oncol 5 : 5 ~ 23
[학술지(정기간행물)] - Goldhirsch A. / 2013 / Personalizing the treatment of women with early breast cancer : highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24 : 2206 ~ 2223
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UCI(KEPA) : I410-ECN-0101-2016-514-002399253