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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1,031 - 1,037 (7page)
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The purpose of this study was to investigate the correlations between tumor-to-background ratio (TBR) obtained from breast-specific gamma imaging (BSGI) and the prognostic factors of breast cancer. Sixty-seven patients with invasive ductal carcinoma who underwent preoperative BSGI were enrolled. The BSGI images were visually scored from 1 to 5 according to a breast imaging reporting and data system (BIRADS). The TBR results obtained from positive BSGI images were compared according to the following prognostic factors: tumor size; axillary lymph node metastasis; nuclear grade (NG); histologic grade (HG); subtype; Ki-67; and the expression profile of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Among 67 images, 60 were classified as a positive finding (sensitivity 89.6%). A higher TBR value was significantly correlated with tumor size ≥ 2 cm (P = 0.001), axillary lymph node metastasis (P = 0.007), high HG (P = 0.029), negative PR status (P = 0.036), and Ki-67 ≥ 14% (P = 0.007). The TBR showed a significant difference between the luminal A and non-luminal A subtypes (P = 0.007). On multivariate analysis, TBR had a high correlation with tumor size ≥ 2 cm, axillary lymph node metastasis, and negative PR status (P = 0.003, 0.048, and 0.030, respectively). A high TBR on BSGI was significantly correlated with poor prognostic factors of breast cancer. Luminal A subtype, a breast cancer subtype with more favorable prognosis, was associated with a low TBR on BSGI.
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참고문헌 (24)
참고문헌 신청
Early Breast Cancer Trialists’ Collaborative Group(EBCTCG) / 2005 / Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival : an overview of the randomised trials / Lancet 365:1687~1717
Olsen AH / 2005 / Breast cancer mortality in Copenhagen after introduction of mammography screening : cohort study / BMJ 330:220
Stomper PC / 1996 / Analysis of parenchymal density on mammograms in 1353 women 25–79 years old / AJR Am J Roentgenol 167:1261~1265
Lee A / 2012 / Effectiveness of breast-specific gamma imaging(BSGI)for breast cancer in Korea : a comparative study / Breast J 18:453~458
Sun Y / 2013 / Clinical usefulness of breast-specific gamma imaging as an adjunct modality to mammography for diagnosis of breast cancer : a systemic review and meta-analysis / Eur J Nucl Med Mol Imaging 40:450~463
Olsen AH / 2005 / Breast cancer mortality in Copenhagen after introduction of mammography screening : cohort study / BMJ 330:220
Stomper PC / 1996 / Analysis of parenchymal density on mammograms in 1353 women 25–79 years old / AJR Am J Roentgenol 167:1261~1265
Lee A / 2012 / Effectiveness of breast-specific gamma imaging(BSGI)for breast cancer in Korea : a comparative study / Breast J 18:453~458
Sun Y / 2013 / Clinical usefulness of breast-specific gamma imaging as an adjunct modality to mammography for diagnosis of breast cancer : a systemic review and meta-analysis / Eur J Nucl Med Mol Imaging 40:450~463
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