Organ-Specific Recurrence or Metastatic Pattern of Breast Cancer according to Biological Subtypes and Clinical Characteristics

Jaeyoon Kim; Yujin Lee; Taeyong Yoo; Jungbin Kim; Jonghee Hyun; Inseok Park; Hyunjin Cho; Keunho Yang; Byungno Bae; Kihwan Kim; Kyeongmee Park; Geumhee Gwak

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자료유형: 학술저널

저자정보: Jaeyoon Kim Yujin Lee Taeyong Yoo Jungbin Kim Jonghee Hyun Inseok Park Hyunjin Cho Keunho Yang Byungno Bae Kihwan Kim Kyeongmee Park Geumhee Gwak

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제7권 제1호

발행연도: 2019.1

수록면: 30 - 37 (8page)

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2019

Organ-Specific Recurrence or Metastatic Pattern of Breast Cancer according to Biological Subtypes and Clinical Characteristics

Jaeyoon Kim , Yujin Lee , Taeyong Yoo 외 11명 Journal of Breast Disease 2019.01 학술저널

2018

Organ Specific Recurrence or Metastasis Pattern of Breast Cancer by Biological Subtypes and Clinical Characteristics

Jaeyoon Kim , Yujin Lee , Taeyong Yoo 외 10명 대한외과학회 학술대회 초록집 2018.11 학술대회자료

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Purpose: We aimed to investigate organ-specific recurrence or the metastatic pattern of breast cancer according to biological subtypes and clinical characteristics. Methods: We retrospectively analyzed the medical records of 168 patients with recurrent breast cancer who were diagnosed between January 1, 2000 and April 30, 2017. Four biological subtypes were classified according to estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2), and Ki-67 expression: luminal A, luminal B, HER2-enriched, and triple negative breast cancer (TNBC). To analyze recurrence patterns according to biological subtypes, we accessed clinical variables including age at diagnosis, TNM stage, type of surgery in the breast and axilla, histologic grade, nuclear grade, lymphatic, vascular, and neural invasion, Ki-67 expression and recurrence to distant organs. Results: The biological subtypes of recurrent breast cancer comprised the following luminal A (n=33, 19.6%), luminal B (n=95, 56.5%), HER2 enriched (n=19, 11.3%), and TNBC (n=21, 12.5%). Luminal A (7.7%) and B (6.5%) subtypes were associated with the increased rate of local recurrence compared to HER2-enriched (2.4%) and TNBC subtypes (1.8%) (p=0.005). The bone (53.6%) was the most common metastatic organ, followed by the lung (34.5%), liver (29.8%), brain (17.9%), and other visceral organ (7.7%). Bone metastasis was commonly observed in individuals with luminal B (63.2%), HER2-enriched (57.9%), and luminal A (42.4%) subtypes (p=0.005). Most liver metastases occur in individuals with luminal B (40.0%) and HER2-enriched subtypes (31.6%) (p=0.002). Conclusion: Luminal B subtype was commonly observed in individuals with recurrent breast cancer, and the bone is the most common target organ for breast cancer metastasis, followed by the lungs and liver.

참고문헌 (29)

참고문헌 신청

Prat A / 2015 / Clinical implications of the intrinsic molecular subtypes of breast cancer / Breast 24(Suppl 2):S26~S35

Prat A / 2011 / Deconstructing the molecular portraits of breast cancer / Mol Oncol 5:5~23

Goldhirsch A / 2013 / Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013 / Ann Oncol 24:2206~2223

Howlader N / 2014 / US incidence of breast cancer subtypes defined by joint hormone receptor and HER2 status / J Natl Cancer Inst 106

Althuis MD / 2004 / Etiology of hormone receptor-defined breast cancer: a systematic review of the literature / Cancer Epidemiol Biomarkers Prev 13:1558~1568

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