지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 21 - 33 (13page)
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초록· 키워드
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Dichlorodiphenyltrichloroethane (DDT) is still used in certain areas of tropics and subtropics to control malaria and other insect-transmitted diseases. DDT and its metabolites have been extensively studied for their toxicity and carcinogenicity in animals and humans and shown to have an endocrine disrupting potential affecting reproductive system although the effects may vary among animal species in correlation with exposure levels. Epidemiologic studies revealed either positive or negative associations between exposure to DDT and tumor development, but there has been no clear evidence that DDT causes cancer in humans. In experimental animals, tumor induction by DDT has been shown in the liver, lung, and adrenals. The mechanisms of hepatic tumor development by DDT have been studied in rats and mice. DDT is known as a non-genotoxic hepatocarcinogen and has been shown to induce microsomal enzymes through activation of constitutive androstane receptor (CAR) and to inhibit gap junctional intercellular communication (GJIC) in the rodent liver. The results from our previously conducted 4-week and 2-year feeding studies of p,p"-DDT in F344 rats indicate that DDT may induce hepatocellular eosinophilic foci as a result of oxidative DNA damage and leads them to hepatic neoplasia in combination with its mitogenic activity and inhibitory effect on GJIC. Oxidative stress could be a key factor in hepatocarcinogenesis by DDT.
목차
INTRODUCTION
CONCLUSIONS
REFERENCES
참고문헌 (41)
참고문헌 신청
ATSDR. (2002) Toxicological profile for DDT, DDE and DDD. U.S. department of health and human services. Public health service. Agency for toxic substances and disease registry.
Vos, J.G., Dybing, E., Greim, H.A., Ladefoged, O., Lambré, C., Tarazona, J.V., Brandt, I. and Vethaak, A.D. (2000) Health effects of endocrine-disrupting chemicals on wildlife, with special reference to European situation. Crit. Rev. Toxicol., 30, 71-133.
WHO. (2008) World malaria report 2008. Global malaria program. World health organization.
International Agency for Research on Cancer (IARC). (1991) Occupational exposures in insecticide application, and some pesticides. IARC monographs on the evaluation of carcinogenic risks to humans, 53, 179-249.
Harada, T., Yamaguchi, S., Ohtsuka, R., Takeda, M., Fujisawa, H., Yoshida, T., Enomoto, A., Chiba, Y., Fukumori, J., Kojima, S., Tomiyama, N., Saka, M., Ozaki, M. and Maita, K. (2003) Mechanisms of promotion and progression of preneoplastic lesions in hepatocarcinogenesis by DDT in F344 rats. Toxicol. Pathol., 31, 87-98.
Vos, J.G., Dybing, E., Greim, H.A., Ladefoged, O., Lambré, C., Tarazona, J.V., Brandt, I. and Vethaak, A.D. (2000) Health effects of endocrine-disrupting chemicals on wildlife, with special reference to European situation. Crit. Rev. Toxicol., 30, 71-133.
WHO. (2008) World malaria report 2008. Global malaria program. World health organization.
International Agency for Research on Cancer (IARC). (1991) Occupational exposures in insecticide application, and some pesticides. IARC monographs on the evaluation of carcinogenic risks to humans, 53, 179-249.
Harada, T., Yamaguchi, S., Ohtsuka, R., Takeda, M., Fujisawa, H., Yoshida, T., Enomoto, A., Chiba, Y., Fukumori, J., Kojima, S., Tomiyama, N., Saka, M., Ozaki, M. and Maita, K. (2003) Mechanisms of promotion and progression of preneoplastic lesions in hepatocarcinogenesis by DDT in F344 rats. Toxicol. Pathol., 31, 87-98.
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UCI(KEPA) : I410-ECN-0101-2016-513-002333905