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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.12
- 수록면
- 188 - 197 (10page)
이용수
초록· 키워드
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In this study, we investigated the effect of rice bran water extract fermented with Lactobacillus plantarum Hong (RBLw), on activities of cyclooxygenase-1 (COX-1) and thromboxane A₂ synthase (TXAS), thromboxane A₂ (TXA₂) production associated microsomal enzymes and evaluated its the antiplatelet effect. RBLw, containing 13.5 mg of ferulic acid, dose-dependently inhibited ADP-induced platelet aggregation, and inhibited the production of TXA₂, an aggregation molecule. In addition, RBLw directly inhibited COX-1 activity in a dose-dependent manner, but not TXAS activity in platelet microsomal fraction having cytochrome c reductase (an endoplasmic reticulum marker enzyme) activity and expressing COX-1 (72 kDa) and TXAS (60.5 kDa) proteins. These results suggest that RBLw selectively inhibited the activity of COX-1 rather than TXAS to attenuate TXA₂ production in ADP-activated platelets. Thus, we demonstrate that RBLw might have direct COX-1 antagonistic function for platelet aggregation-mediated diseases, such as thrombosis, myocardial infarction, atherosclerosis, and ischemic cerebrovascular disease.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (30)
참고문헌 신청
[학술지(정기간행물)] - 백승은 / 2014 / Neuroprotective effect of rice bran extract supplemented with ferulic acid in the rat model of ischemic brain injury / Animal Cells and Systems 18 (2) : 93 ~ 100
[학술지(정기간행물)] - Carey F / 1982 / Localization of cyclo-oxygenase and thromboxane synthase in human platelet intracellular membranes / Biochem J 204 : 847 ~ 851
[학술지(정기간행물)] - Cattaneo M / 1991 / In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production / Thromb Res 62 : 717 ~ 724
[학술지(정기간행물)] - Clutton P / 2001 / Pharmacological control of platelet function / Pharmacol Res 44 : 255 ~ 264
[학술지(정기간행물)] - DeWitt DL / 1990 / The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases / J Biol Chem 265 : 5192 ~ 5198
[학술지(정기간행물)] - Carey F / 1982 / Localization of cyclo-oxygenase and thromboxane synthase in human platelet intracellular membranes / Biochem J 204 : 847 ~ 851
[학술지(정기간행물)] - Cattaneo M / 1991 / In vitro effects of picotamide on human platelet aggregation, the release reaction and thromboxane B2 production / Thromb Res 62 : 717 ~ 724
[학술지(정기간행물)] - Clutton P / 2001 / Pharmacological control of platelet function / Pharmacol Res 44 : 255 ~ 264
[학술지(정기간행물)] - DeWitt DL / 1990 / The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases / J Biol Chem 265 : 5192 ~ 5198
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UCI(KEPA) : I410-ECN-0101-2016-510-002321988