지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.10
- 수록면
- 222 - 231 (10page)
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초록· 키워드
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Minor histocompatibility antigens are MHC-bound peptides and contribute to the generation of allo-responses after allogeneic transplantation. H60 is a dominant minor H antigen that induces a strong CD8 T-cell response in MHC-matched allogeneic transplantation settings. Here, we report establishment of a TCR transgenic mouse line named J15, wherein T cells express TCRs specific for H60 in complex with H-2K<SUP>b</SUP>, and different fates of the thymocytes expressing J15 TCRs in various thymic antigenic environments. Thymocytes expressing the J15 TCRs were positively selected and differentiated into CD8⁺ single positive (SP) cells in the thymus of C57BL/6 mice, wherein the cognate antigen H60 is not expressed. However, thymocytes were negatively selected in thymus tissue where H60 was transgenically expressed under the control of the actin promoter, with double-positive stages of cells being deleted. Despite the ability of the H60H peptide (LTFHYRNL) variant to induce cytotoxic activity from H60-specific CTL lines at ∼50% of the activity induced by normal H60 peptides (LTFNYRNL), J15-expressing thymocytes were positively selected in the thymus where the variant H60H was transgenically expressed. These results demonstrate that a single amino-acid change in the H60 epitope peptide influences the fate of thymocytes expressing the cognate TCR.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
[학술지(정기간행물)] - Roopenian, D. / 2002 / The immunogenomics of minor histocompatibility antigens / Immunol. Rev 190 : 86 ~ 94
[학술지(정기간행물)] - Choi, E. Y. / 2001 / Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others / J. Immunol 166 : 4370 ~ 4379
[학술지(정기간행물)] - Choi, E. Y. / 2002 / Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease / Blood 100 : 4259 ~ 4265
[학술지(정기간행물)] - Choi, J. H. / 2009 / TCR diversity of H60-specific CD8 T cells during the response evolution influence of CD4 help / Transplantation 87 : 1609 ~ 1616
[학술지(정기간행물)] - Ryu, S. J. / 2009 / Cognate CD4 help is essential for the reactivation expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60 / Blood 113 : 4273 ~ 4280
[학술지(정기간행물)] - Choi, E. Y. / 2001 / Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others / J. Immunol 166 : 4370 ~ 4379
[학술지(정기간행물)] - Choi, E. Y. / 2002 / Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease / Blood 100 : 4259 ~ 4265
[학술지(정기간행물)] - Choi, J. H. / 2009 / TCR diversity of H60-specific CD8 T cells during the response evolution influence of CD4 help / Transplantation 87 : 1609 ~ 1616
[학술지(정기간행물)] - Ryu, S. J. / 2009 / Cognate CD4 help is essential for the reactivation expansion of CD8 memory T cells directed against the hematopoietic cell-specific dominant minor histocompatibility antigen, H60 / Blood 113 : 4273 ~ 4280
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UCI(KEPA) : I410-ECN-0101-2016-511-002009668