DEAD/DExH-Box RNA Helicases in Selected Human Parasites

Laurence A. Marchat; Silvia I. Arzola-Rodríguez; Olga Hernandez-de la Cruz; Itzel Lopez-Rosas; Cesar Lopez-Camarillo

추천

검색

질문

자료유형: 학술저널

저자정보: Laurence A. Marchat (National School of Medicine and Homeopathy of the National Polytechnic Institute) Silvia I. Arzola-Rodríguez (Autonomous University of Mexico City) Olga Hernandez-de la Cruz (Autonomous University of Mexico City) Itzel Lopez-Rosas (National School of Medicine and Homeopathy of the National Polytechnic Institute) Cesar Lopez-Camarillo (Autonomous University of Mexico City)

저널정보: 대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.53 No.5

발행연도: 2015.10

수록면: 583 - 595 (13page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

DEAD/DExH-box RNA helicases catalyze the folding and remodeling of RNA molecules in prokaryotic and eukaryotic cells, as well as in many viruses. They are characterized by the presence of the helicase domain with conserved motifs that are essential for ATP binding and hydrolysis, RNA interaction, and unwinding activities. Large families of DEAD/DExH-box proteins have been described in different organisms, and their role in all molecular processes involving RNA, from transcriptional regulation to mRNA decay, have been described. This review aims to summarize the current knowledge about DEAD/DExH-box proteins in selected protozoan and nematode parasites of medical importance worldwide, such as Plasmodium falciparum, Leishmania spp., Trypanosoma spp., Giardia lamblia, Entamoeba histolytica, and Brugia malayi. We discuss the functional characterization of several proteins in an attempt to understand better the molecular mechanisms involving RNA in these pathogens. The current data also highlight that DEAD/DExH-box RNA helicases might represent feasible drug targets due to their vital role in parasite growth and development.

#RNA helicase #protozoa #nematode #RNA metabolism

참고문헌 (73)

참고문헌 신청

[학술지(정기간행물)] - Gorbalenya A / 1993 / Helicases: amino acid sequence comparisons and structure-function relationships / Curr Biol 3 : 419 ~ 429

[학술지(정기간행물)] - Linder P / 2006 / Dead-box proteins: a family affair--active and passive players in RNP-remodeling / Nucleic Acids Res 34 : 4168 ~ 4180

[학술지(정기간행물)] - Fairman-Williams ME / 2010 / SF1 and SF2 helicases: family matters / Curr Opin Struct Biol 20 : 313 ~ 324

[학술지(정기간행물)] - Cordin O / 2006 / The DEAD-box protein family of RNA helicases / Gene 367 : 17 ~ 37

[학술지(정기간행물)] - Henn A / 2012 / ATP utilization and RNA conformational rearrangement by DEAD-box proteins / Annu Rev Biophys 41 : 247 ~ 267

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!