지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.8
- 수록면
- 206 - 211 (6page)
이용수
초록· 키워드
오류제보하기
Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-δ (PKC-δ) in ALI has been a controversial topic. Here we investigated PKC-δ function in ALI using PKC-δ knockout (KO) mice and PKC inhibitors. Our results indicated that although the ability to produce proinflammatory mediators in response to LPS injury in PKC-δ KO mice was similar to that of control mice, they showed enhanced recruitment of neutrophils to the lung and more severe pulmonary edema. PKC-δ inhibition promoted barrier dysfunction in an endothelial cell layer in vitro, and administration of a PKC-δ-specific inhibitor significantly increased steady state vascular permeability. A neutrophil transmigration assay indicated that the PKC-δ inhibition increased neutrophil transmigration through an endothelial monolayer. This suggests that PKC-δ inhibition induces structural changes in endothelial cells, allowing extravasation of proteins and neutrophils.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (11)
참고문헌 신청
[학술지(정기간행물)] - Han, S. / 2015 / The acute respiratory distress syndrome: from mechanism to translation / J. Immunol 194 : 855 ~ 860
[학술지(정기간행물)] - Siflinger-Birnboim A. / 2003 / Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury / Am. J. Physiol. Lung Cell. Mol. Physiol 284 : L435 ~ L451
[학술지(정기간행물)] - Klinger, J. R. / 2007 / Rottlerin causes pulmonary edema in vivo: a possible role for PKCδ / J. Appl. Physiol 103 : 2084 ~ 2094
[학술지(정기간행물)] - Gaudreault, N. R. M. / 2008 / Counter regulatory effects of PKCβII PKCδ on coronary endothelial permeability / Arterioscler. Thromb. Vasc. Biol 28 : 1527 ~ 1533
[학술지(정기간행물)] - Chichger, H. K. / 2012 / Genetic disruption of protein of protein kinase Cδ reduces endotoxin-induced lung injury / Am. J. Physiol. Lung Cell. Mol. Physiol 303 : L880 ~ L888
[학술지(정기간행물)] - Siflinger-Birnboim A. / 2003 / Protein kinase C modulates pulmonary endothelial permeability: a paradigm for acute lung injury / Am. J. Physiol. Lung Cell. Mol. Physiol 284 : L435 ~ L451
[학술지(정기간행물)] - Klinger, J. R. / 2007 / Rottlerin causes pulmonary edema in vivo: a possible role for PKCδ / J. Appl. Physiol 103 : 2084 ~ 2094
[학술지(정기간행물)] - Gaudreault, N. R. M. / 2008 / Counter regulatory effects of PKCβII PKCδ on coronary endothelial permeability / Arterioscler. Thromb. Vasc. Biol 28 : 1527 ~ 1533
[학술지(정기간행물)] - Chichger, H. K. / 2012 / Genetic disruption of protein of protein kinase Cδ reduces endotoxin-induced lung injury / Am. J. Physiol. Lung Cell. Mol. Physiol 303 : L880 ~ L888
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UCI(KEPA) : I410-ECN-0101-2016-511-001834878