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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 115 - 122 (8page)
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초록· 키워드
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Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain obscure. In this study, we investigated the relationship between melatonin (MT) and dopamine D2-like receptor signaling in pentobarbital-induced sleep and the intracellular mechanisms of sleep maintenance in the cerebral cortex. In mice, pentobarbital-induced sleep was augmented by intraperitoneal administration of 30 mg/kg MT. To investigate the relationship between MT and D2-like receptors, we administered quinpirole, a D2-like receptor agonist, to MT- and pentobarbital-treated mice. Quinpirole (1 mg/kg, i.p.) increased the duration of MT-augmented sleep in mice. In addition, locomotor activity analysis showed that neither MT nor quinpirole produced sedative effects when administered alone. In order to understand the mechanisms underlying quinpirole-augmented sleep, we measured protein levels of mitogen-activated protein kinases (MAPKs) and cortical protein kinases related to MT signaling. Treatment with quinpirole or MT activated extracellular-signal-regulated kinase 1 and 2 (ERK1/2), p38 MAPK, and protein kinase C (PKC) in the cerebral cortex, while protein kinase A (PKA) activation was not altered significantly. Taken together, our results show that quinpirole increases the duration of MT-augmented sleep through ERK1/2, p38 MAPK, and PKC signaling. These findings suggest that modulation of D2-like receptors might enhance the effect of MT on sleep.
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참고문헌 (44)
참고문헌 신청
Abrial, E / 2015 / Protein kinase C inhibition rescues manic-like behaviors and hippocampal cell proliferation deficits in the sleep deprivation model of mania / Int. J. Neuropsychopharmacol 18:pyu031
Binfaré, R. W / 2010 / Involvement of dopamine receptors in the antidepressant-like effect of melatonin in the tail suspension test / Eur. J. Pharmacol 638:78~83
Bondi, C. D / 2008 / MT1melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation / J. Pineal Res 44:288~298
Brandon, N. J / 2000 / GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway / J. Biol. Chem 275:38856~38862
Brandon, N. J / 2002 / Receptor for activated C kinase-1 facilitates protein kinase Cdependent phosphorylation and functional modulation of GABAA receptors with the activation of G-protein-coupled receptors / J. Neurosci 22:6353~6361
Binfaré, R. W / 2010 / Involvement of dopamine receptors in the antidepressant-like effect of melatonin in the tail suspension test / Eur. J. Pharmacol 638:78~83
Bondi, C. D / 2008 / MT1melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation / J. Pineal Res 44:288~298
Brandon, N. J / 2000 / GABAA receptor phosphorylation and functional modulation in cortical neurons by a protein kinase C-dependent pathway / J. Biol. Chem 275:38856~38862
Brandon, N. J / 2002 / Receptor for activated C kinase-1 facilitates protein kinase Cdependent phosphorylation and functional modulation of GABAA receptors with the activation of G-protein-coupled receptors / J. Neurosci 22:6353~6361
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