지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 503 - 511 (9page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.503
이용수
초록· 키워드
오류제보하기
Lysophosphatidic acid (LPA) is known to play a critical role in breast cancer metastasis to bone. In this study, we tried to investigate any role of LPA in the regulation of osteoclastogenic cytokines from breast cancer cells and the possibility of these secretory factors in affecting osteoclastogenesis. Effect of secreted cytokines on osteoclastogenesis was analyzed by treating conditioned media from LPA-stimulated breast cancer cells to differentiating osteoclasts. Result demonstrated that IL-8 and IL-11 expression were upregulated in LPA-treated MDA-MB-231 cells. IL-8 was induced in both MDA-MB-231 and MDA-MB-468, however, IL-11 was induced only in MDA-MB-231, suggesting differential LPARs participation in the expression of these cytokines. Expression of IL-8 but not IL-11 was suppressed by inhibitors of PI3K, NFkB, ROCK and PKC pathways. In the case of PKC activation, it was observed that PKCδ and PKCμ might regulate LPA-induced expression of IL-11 and IL-8, respectively, by using specific PKC subtype inhibitors. Finally, conditioned Medium from LPA-stimulated breast cancer cells induced osteoclastogenesis. In conclusion, LPA induced the expression of osteolytic cytokines (IL-8 and IL-11) in breast cancer cells by involving different LPA receptors. Enhanced expression of IL-8 by LPA may be via ROCK, PKCu, PI3K, and NFkB signaling pathways, while enhanced expression of IL-11 might involve PKCδ signaling pathway. LPA has the ability to enhance breast cancer cells-mediated osteoclastogenesis by inducing the secretion of cytokines such as IL-8 and IL-11.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
Lin Y / 2004 / Identification of interleukin-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays / Int J Cancer 109:507~515
Yao C / 2007 / Interleukin-8 modulates growth and invasiveness of estrogen receptornegative breast cancer cells / Int J Cancer 121:1949~1957
Li A / 2003 / IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis / J Immunol 170:3369~3376
Martin D / 2009 / CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex / J Biol Chem 284:6038~6042
Lin Y / 2004 / Identification of interleukin-8 as estrogen receptor-regulated factor involved in breast cancer invasion and angiogenesis by protein arrays / Int J Cancer 109:507~515
Yao C / 2007 / Interleukin-8 modulates growth and invasiveness of estrogen receptornegative breast cancer cells / Int J Cancer 121:1949~1957
Li A / 2003 / IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis / J Immunol 170:3369~3376
Martin D / 2009 / CXCL8/IL8 stimulates vascular endothelial growth factor (VEGF) expression and the autocrine activation of VEGFR2 in endothelial cells by activating NFkappaB through the CBM (Carma3/Bcl10/Malt1) complex / J Biol Chem 284:6038~6042
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Regulation of Osteoclast Differentiation by Cytokine Networks
Immune Network
2018 .02
-
Expression of Il4rα and Il13rα1 in Gallbladder Cancer
대한외과학회 학술대회 초록집
2021 .11
-
IL-1 Receptor Dynamics in Immune Cells: Orchestrating Immune Precision and Balance
Immune Network
2024 .06
-
Out-sourcing for Trans-presentation : Assessing T Cell Intrinsic and Extrinsic IL-15 Expression with Il15 Gene Reporter Mice
Immune Network
2018 .02
-
Expression of IL4Ra and IL13Rα1 in gallbladder cancer
대한임상종양학회 학술대회지
2022 .02
-
Facile Titrimetric Assay of Lysophosphatidic Acid in Human Serum and Plasma for Ovarian Cancer Detection
대한암예방학회지
2023 .06
-
I-Kappa-B-Zeta Regulates Interleukin-17A/Tumor Necrosis Factor-Alpha Mediated Synergistic Induction of Interleukin-19 and Interleukin-20 in Humane Keratinocytes
Annals of Dermatology
2021 .01
-
Enhanced Type 2 Immune Reactions by Increased IL-22/IL-22Ra1 Signaling in Chronic Rhinosinusitis With Nasal Polyps
Allergy, Asthma & Immunology Research
2020 .01
-
Interleukin-18 Receptor α Modulates the T Cell Response in Food Allergy
Allergy, Asthma & Immunology Research
2022 .07
-
Effect of STAT3 on Lysophosphatidic Acid-Induced Oral Cancer Cell Invasion
치위생과학회지
2019 .01
-
Role of TAZ in Lysophosphatidic Acid-Induced Migration and Proliferation of Human Adipose-Derived Mesenchymal Stem Cells
Biomolecules & Therapeutics(구 응용약물학회지)
2017 .01
-
Induction of Unique STAT Heterodimers by IL-21 Provokes IL-1RI Expression on CD8+ T Cells, Resulting in Enhanced IL-1β Dependent Effector Function
Immune Network
2021 .10
-
Association of Single Nucleotide Polymorphisms in Interleukin-12 Receptor (IL-12Rβ1 and IL-12Rβ2) with Asthma in a Korean Population
대한의생명과학회지
2020 .12
-
IL-34 Aggravates Steroid-Induced Osteonecrosis of the Femoral Head via Promoting Osteoclast Differentiation
Immune Network
2022 .06
-
Breast Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Breast Cancer
대한외과학회 학술대회 초록집
2020 .11
-
Breast Cancer
대한외과학회 학술대회 초록집
2020 .11
-
Tp53 Mutation Is Linked with High 21-Gene Recurrence Score in ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2021 .05
-
Breast Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Predictive Factors of Pathologic N2/N3 Disease in Clinical or Pathologic N1 ER+/HER2- Breast Cancer
대한외과학회 학술대회 초록집
2023 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0