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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.12
- 수록면
- 181 - 187 (7page)
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Excessive alcohol consumption is one of the critical causative factors leading to alcoholic liver disease (ALD). ALD is characterized by a wide spectrum of liver damage, ranging from simple uncomplicated liver steatosis (fatty liver) to steatohepatitis and liver fibrosis/cirrhosis. It has been believed that the obvious underlying cause for ALD is due to hepatocyte death induced by alcohol itself. However, recent sparkling studies have shown that diverse immune responses contribute to ALD because liver is enriched with numerous immune cells. Especially, a line of evidence has suggested that innate immune cells such as Kupffer cells and natural killer (NK)/NKT cells are significantly involved in the pathogenesis of ALD via production of pro-inflammatory cytokines and other mediators. Indeed, more interestingly, hepatic stellate cells (HSCs), known as a major cell inducing liver steatosis and fibrosis, can be killed by liver NK cells, which could be suppressed by chronic alcohol consumption. In this review, with the view of liver as predominant innate immune organ, we describe the pathogenesis of ALD in which what roles of innate immune cells are and how they are interacting with HSCs.
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참고문헌 (65)
참고문헌 신청
1. [학술지(정기간행물)] - Williams R / 2006 / Global challenges in liver disease / Hepatology 44 : 521 ~ 526
2. [학술지(정기간행물)] - O’Shea RS / 2010 / Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology: Alcoholic liver disease / Hepatology 51 : 307 ~ 328
3. [학술지(정기간행물)] - Jeong WI / 2008 / Innate immunity and alcoholic liver fibrosis / J Gastroenterol Hepatol 23 (1) : S112 ~ S118
4. [학술지(정기간행물)] - Purohit V / 2009 / Molecular mechanisms of alcoholic fatty liver / Alcohol Clin Exp Res 33 : 191 ~ 205
5. [학술지(정기간행물)] - Purohit V / 2006 / Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium / Hepatology 43 : 872 ~ 878
2. [학술지(정기간행물)] - O’Shea RS / 2010 / Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology: Alcoholic liver disease / Hepatology 51 : 307 ~ 328
3. [학술지(정기간행물)] - Jeong WI / 2008 / Innate immunity and alcoholic liver fibrosis / J Gastroenterol Hepatol 23 (1) : S112 ~ S118
4. [학술지(정기간행물)] - Purohit V / 2009 / Molecular mechanisms of alcoholic fatty liver / Alcohol Clin Exp Res 33 : 191 ~ 205
5. [학술지(정기간행물)] - Purohit V / 2006 / Mechanisms of alcohol-induced hepatic fibrosis: a summary of the Ron Thurman Symposium / Hepatology 43 : 872 ~ 878
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