지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.4
- 수록면
- 46 - 54 (9page)
이용수
초록· 키워드
오류제보하기
Graft-versus-host disease (GVHD) is initiated when alloreactive donor T cells are primed by host APCs to undergo clonal expansion and maturation. Since there is a controversy regarding the role of nonhematopoietic cells in GVHD, we wanted to investigate the influence of MHC disparity on nonhematopoietic cells on the pathogenesis of GVHD in the MHC-haplomismatched C57BL/6 (H-2<sup>b</sup>) or DBA/2 (H-2<sup>b</sup>)→unirradiated (C57BL/6×DBA/2) F<sub>1</sub>(BDF<sub>1</sub>H-2<sup>b/d</sup>) murine model of acute GVHD (aGVHD) or chronic GVHD (cGVHD). Methods: We generated (BDF<sub>1</sub>→C57BL/6), (BDF<sub>1</sub>→DBA/2), and (BDF1→BDF<sub>1</sub>) chimeras and examined GVHD-related parameters and donor cell engraftment in those chimeras. Results: Using this experimental system, we found that 1) severe aGVHD across MHC Ag barrier depends on the expression of nonhematopoietically rather than hematopoietically derived alloAgs for maximal GVHD manifestations; 2) host APCs were sufficient to break B cell tolerance to self molecules in cGVHD, whereas host APCs were insufficient to induce autoimmunity in aGVHD; 3) donor cell engraftment was greatly enhanced in the host with MHC-matched nonhematopoietic cells. Conclusion: Taken together, our results provide an insight into how MHC disparity on GVHD target organs contribute to the pathogenesis of GVHD.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Skewed Dendritic Cell Differentiation of MyD88-Deficient Donor Bone Marrow Cells, Instead of Massive Expansion as Myeloid-Derived Suppressor Cells, Aggravates GVHD
Immune Network
2018 .12
-
Kinetics of IFN-γ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease
Immune Network
2014 .04
-
Graft-Versus-Host Disease after Liver Transplantation
Annals of Hepato-Biliary-Pancreatic Surgery
2010 .12
-
Evaluation of risk for graft-versus-host disease in children who receive less than the full doses of mini-dose methotrexate for graft-versus-host disease prophylaxis in allogeneic hematopoietic stem cell transplantation
Clinical and Experimental Pediatrics
2013 .01
-
Graft versus host disease (GVHD) after liver transplantation (LT) focused on deceased donor LT (DDLT) : A propensity score-matched study
한국간담췌외과학회 학술대회지
2016 .04
-
Effects of Pre-conditioning dose on the Immune Kinetics and Cytokine Production in the Leukocytes Infiltrating GVHD Tissues after MHC-matched Transplantation
Immune Network
2011 .02
-
Stepwise Endoscopy Based on Sigmoidoscopy in Evaluating Pediatric Graft-versus-Host Disease
Pediatric Gastroenterology, Hepatology & Nutrition
2016 .01
-
Circulating Levels of Adipokines Predict the Occurrence of Acute Graft-versus-host Disease
Immune Network
2015 .04
-
Prognostic Implications of the NIH Consensus Criteria in Children with Chronic Graft-versus-Host Disease
Yonsei Medical Journal
2011 .01
-
TLR/MyD88-mediated Innate Immunity in Intestinal Graft-versus-Host Disease
Immune Network
2017 .06
-
Mouse models for graft-versus-host disease
한국실험동물학회 학술발표대회 논문집
2010 .08
-
A Case of Chronic Cutaneous Graft Versus Host Disease with the Clinical Features of Exfoliative Dermatitis
Annals of Dermatology
2009 .01
-
Mesenchymal Stem Cell Lines Isolated by Different Isolation Methods Show Variations in the Regulation of Graft-versus-host Disease
Immune Network
2013 .08
-
Gut Microbiota in Graft-versus-Host Disease
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .12
-
사람의 동종 조혈모세포이식에서 CD4CD25 T세포의 분포와 이식편대숙주병
Clinical and Experimental Pediatrics
2008 .01
-
Skin Graft-versus-host Disease Following Autologous Stem Cell Transplantation for Multiple Myeloma
Immune Network
2013 .06
-
Gynecologic complication of chronic graft-versus-host disease: Vaginal obstruction
Obstetrics & Gynecology Science
2013 .01
-
Anti-CD137 mAb Deletes Both Donor CD4+ and CD8+ T Cells in Acute Graft-versus-host Disease
Immune Network
2011 .12
이 논문의 저자 정보
최근 본 자료
댓글(0)
0