지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.8
- 수록면
- 133 - 140 (8page)
이용수
초록· 키워드
오류제보하기
Since the discovery of the immunomodulation property of mesenchymal stem cells (MSCs) about a decade ago, it has been extensively investigated whether MSCs can be used for the treatment of immune-related diseases, such as graftversus-host disease (GvHD). However, how to evaluate the efficacy of human MSCs for the clinical trial is still unclear. We used an MHC-mismatched model of GvHD (B6 into BALB/c). Surprisingly, the administration of the human MSCs (hMSCs) could reduce the GvHD-related mortality of the mouse recipients and xenogeneically inhibit mouse T-cell proliferation and IFN-γ production in vitro. We recently established a new protocol for the isolation of a homogeneous population of MSCs called subfractionation culturing methods (SCM), and established a library of clonal MSC lines. Therefore, we also investigated whether MSCs isolated by the conventional gradient centrifugation method (GCM) and SCM show different efficacy in vivo. Intriguingly, clonal hMSCs (hcMSCs) isolated by SCM showed better efficacy than hMSCs isolated by GCM. Based on these results, the MHC-mismatched model of GvHD may be useful for evaluating the efficacy of human MSCs before the clinical trial. The results of this study suggest that different MSC lines may show different efficacy in vivo and in vitro.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Goker, H. / 2001 / Acute graft-vs-host disease: pathobiology and management / Exp. Hematol 29 : 259 ~ 277
2. [학술지(정기간행물)] - Menillo, S. A. / 2001 / Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host disease following allogeneic stem cell transplantation / Bone Marrow. Transplant 28 : 807 ~ 808
3. [학술지(정기간행물)] - Deeg, H. J / 2007 / How I treat refractory acute GVHD / Blood 109 : 4119 ~ 4126
4. [학술지(정기간행물)] - Rager, A. / 2011 / Inflammatory cytokine inhibition with combination daclizumab and infliximab for steroid-refractory acute GVHD / Bone Marrow. Transplant 46 : 430 ~ 435
5. [학술지(정기간행물)] - Schub, N. / 2011 / Therapy of steroid-refractory acute GVHD with CD52 antibody alemtuzumab is effective / Bone Marrow. Transplant 46 : 143 ~ 147
2. [학술지(정기간행물)] - Menillo, S. A. / 2001 / Intraoral psoralen ultraviolet A irradiation (PUVA) treatment of refractory oral chronic graft-versus-host disease following allogeneic stem cell transplantation / Bone Marrow. Transplant 28 : 807 ~ 808
3. [학술지(정기간행물)] - Deeg, H. J / 2007 / How I treat refractory acute GVHD / Blood 109 : 4119 ~ 4126
4. [학술지(정기간행물)] - Rager, A. / 2011 / Inflammatory cytokine inhibition with combination daclizumab and infliximab for steroid-refractory acute GVHD / Bone Marrow. Transplant 46 : 430 ~ 435
5. [학술지(정기간행물)] - Schub, N. / 2011 / Therapy of steroid-refractory acute GVHD with CD52 antibody alemtuzumab is effective / Bone Marrow. Transplant 46 : 143 ~ 147
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UCI(KEPA) : I410-ECN-0101-2016-511-001746088