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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.6
- 수록면
- 59 - 66 (8page)
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CM1 (Centrocyte/-blast Marker I) defined by a mAb developed against concanavalin-A activated PBMC, is expressed specifically on a subpopulation of centroblasts and centrocytes of human germinal center (GC) B cells. Burkitt lymphoma (BL) is a tumor consisting of tumor cells with the characteristics of GC B cell. Previously we reported that CM1 ligation with anti-CM1 mAb induced apoptosis in Ramos (IgM<sup>high</sup>) and Raji IgM<sup>low</sup> cells. Methods & Results: In the present study, we observed that CM1 ligation with anti-CM1 mAb induced Fas ligand and Fas expression in Ramos cells, but not in Raji cells. Furthermore, anti-Fas blocking antibody, ZB4, blocked CM1-mediated apoptosis effectively in Ramos cells, but not in Raji cells. Increased mitochondrial membrane permeabilization, which was measured by DiOC<sub>6</sub>, was observed only in Raji cells. In contrast to no significant change of Bax known as pro-apoptotic protein, anti-apoptotic protein Bcl-2 was significantly decreased in Raji cells. In addition, we observed that CM1 ligation increased release of mitochondrial cytochrome c and upregulated caspase-9 activity in Raji cells. Conclusion: These results suggest that apoptosis induced by CM1-ligation is mediated by Fas-Fas ligand interaction in Ramos cells, whereas apoptosis is mediated by down-regulation of Bcl-2 and subsequent decrease of mitochondrial membrane potential in Raji cells.
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참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - / 2000 / CM1, a possible novel activation molecule on human lymphocytes 74 : 95 ~ 102
[학술지(정기간행물)] - / 1990 / The pathogenesis of Burkitt's lymphoma 55 : 133 ~ 270
[학술지(정기간행물)] - / 1991 / Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis 349 : 612 ~ 614
[학술지(정기간행물)] - / 1998 / Prolonged phenotypic, functional, and molecular change in group I burkitt lymphoma cells on short-term expose to CD40 ligand 92 : 2830 ~ 2843
[학술지(정기간행물)] - / 1987 / Identification of a subset of normal B cells with a Burkitt's lymphoma j immu (l 139) : 313 ~ 318
[학술지(정기간행물)] - / 1990 / The pathogenesis of Burkitt's lymphoma 55 : 133 ~ 270
[학술지(정기간행물)] - / 1991 / Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis 349 : 612 ~ 614
[학술지(정기간행물)] - / 1998 / Prolonged phenotypic, functional, and molecular change in group I burkitt lymphoma cells on short-term expose to CD40 ligand 92 : 2830 ~ 2843
[학술지(정기간행물)] - / 1987 / Identification of a subset of normal B cells with a Burkitt's lymphoma j immu (l 139) : 313 ~ 318
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