지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 67 - 72 (6page)
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The herpes virus entry mediator (HVEM) is a member of the tumor necrosis factor receptor superfamily (TNFRSF), and therefore it is also known as TNFRSF14 or CD270 (1,2). In recent years, we have focused on understanding HVEM function in the mucosa of the intestine, particularly on the role of HVEM in colitis pathogenesis, host defense and regulation of the microbiota (2-4). HVEM is an unusual TNF receptor because of its high expression levels in the gut epithelium, its capacity to bind ligands that are not members of the TNF super family, including immunoglobulin (Ig) superfamily members BTLA and CD160, and its bi-directional functionality, acting as a signaling receptor or as a ligand for the receptor BTLA. Clinically, Hvem recently was reported as an inflammatory bowel disease (IBD) risk gene as a result of genome wide association studies (5,6). This suggests HVEM could have a regulatory role influencing the regulation of epithelial barrier, host defense and the microbiota. Consistent with this, using mouse models, we have revealed how HVEM is involved in colitis pathogenesis, mucosal host defense and epithelial immunity (3,7). Although further studies are needed, our results provide the fundamental basis for understanding why Hvem is an IBD risk gene, and they confirm that HVEM is a mucosal gatekeeper with multiple regulatory functions in the mucosa.
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참고문헌 (15)
참고문헌 신청
1. [학술지(정기간행물)] - Murphy, T. L. / 2010 / Slow down and survive: Enigmatic immunoregulation by BTLA and HVEM / Annu. Rev. Immunol 28 : 389 ~ 411
2. [학술지(정기간행물)] - Shui, J. W. / 2013 / HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes / Gut Microbes 4 : 146 ~ 151
3. [학술지(정기간행물)] - Shui, J. W. / 2012 / HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria / Nature 488 : 222 ~ 225
4. [학술지(정기간행물)] - Steinberg, M. W. / 2009 / Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners / Semin. Immunopathol 31 : 207 ~ 221
5. [학술지(정기간행물)] - Anderson, C. A. / 2011 / Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 / Nat. Genet 43 : 246 ~ 252
2. [학술지(정기간행물)] - Shui, J. W. / 2013 / HVEM: An unusual TNF receptor family member important for mucosal innate immune responses to microbes / Gut Microbes 4 : 146 ~ 151
3. [학술지(정기간행물)] - Shui, J. W. / 2012 / HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria / Nature 488 : 222 ~ 225
4. [학술지(정기간행물)] - Steinberg, M. W. / 2009 / Regulating the mucosal immune system: the contrasting roles of LIGHT, HVEM, and their various partners / Semin. Immunopathol 31 : 207 ~ 221
5. [학술지(정기간행물)] - Anderson, C. A. / 2011 / Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47 / Nat. Genet 43 : 246 ~ 252
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