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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 689 - 697 (9page)
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초록· 키워드
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A vast portion of human disease results when the process of apoptosis is defective. Disorders resulting from inappropriate cell death range from autoimmune and neurodegenerative conditions to heart disease. Conversely, prevention of apoptosis is the hallmark of cancer and confounds the efficacy of cancer therapeutics. In the search for optimal targets that would enable the control of apoptosis, members of the BCL-2 family of anti- and pro-apoptotic factors have figured prominently. Development of BCL-2 antisense approaches, small molecules, and BH3 peptidomimetics has met with both success and failure. Success-because BCL-2 proteins play essential roles in apoptosis. Failure-because single targets for drug development have limited scope. By examining the activity of the BCL-2 proteins in relation to the mitochondrial landscape and drawing attention to the significant mitochondrial membrane alterations that ensue during apoptosis, we demonstrate the need for a broader based multi-disciplinary approach for the design of novel apoptosis-modulating compounds in the treatment of human disease.
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등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Bakhshi A / 1985 / Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around JH on chromosome 14 and near a transcriptional unit on 18 / Cell 41 : 899
Boise LH / 1993 / bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death / Cell 74 : 597 ~ 608
Conradt B / 1998 / The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 / Cell 93 : 519 ~ 529
Farrow SN / 1995 / Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K / Nature 374 : 731 ~ 733
Graninger WB / 1987 / Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells / J Clin Invest 80 : 1512 ~ 1515
Boise LH / 1993 / bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death / Cell 74 : 597 ~ 608
Conradt B / 1998 / The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9 / Cell 93 : 519 ~ 529
Farrow SN / 1995 / Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K / Nature 374 : 731 ~ 733
Graninger WB / 1987 / Expression of Bcl-2 and Bcl-2-Ig fusion transcripts in normal and neoplastic cells / J Clin Invest 80 : 1512 ~ 1515
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