지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.6
- 수록면
- 112 - 125 (14page)
이용수
초록· 키워드
오류제보하기
Bovine tuberculosis caused by Mycobacterium bovis is a major economic problem in several countries. Antibody responses are useful indicators of M. bovis infection of cattle. To overcome drawback of serological tests with low sensitivity, identification and characterization of multiple serodiagnostic antigens has been required. In this study, the antigens with strong antibody reactivity were searched using fractionation of M. bovis culture filtrate proteins and probing with sera from M. bovis-infected cattle. Twelve proteins which have not previously been described as serologic targets were identified and six proteins among them were expressed in Escherichia coli. The mycobacterial lipoarabinomannan (LAM) with strong seroreactivity in cattle was identified and purified. IgG and IgA responses against the newly identified proteins, the seroreactive proteins with strong antibody reactivity in human tuberculosis, and LAM were compared in M. bovis-infected and non-infected cattle as well as in field samples. In general, sensitivity of the tested antigens was higher in M. bovis-infected cattle than purified protein derivative (PPD) (+) field samples. Although a diverse reactivity and sensitivity according to the antigens were shown, the diagnostic utility of both IgA and IgG antibody to the antigens was similar in M. bovis-infected cattle but utility of IgG antibody was superior to that of IgA in field samples. The antigen with the highest diagnostic value was LAM in both the groups. Other antigens with considerable diagnostic utility were BCG_3488c, BCG_2330, Antigen 85, HspX, and Rv3593 when considered the sensitivity and area under the receiver characteristic curve (AUC) value. These antigens may be valuable candidates to be included in a cocktail test kit for bovine tuberculosis diagnosis.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (21)
참고문헌 신청
[학술지(정기간행물)] - Vordermeier HM / 2006 / Progress in the development of vaccines and diagnostic reagents to control tuberculosis in cattle / Vet J 171 : 229 ~ 244
[학술지(정기간행물)] - Neill SD / 1994 / Detection of Mycobacterium bovis infection in skin test-negative cattle with an assay for bovine interferongamma / Vet Rec 135 : 134 ~ 135
[학술지(정기간행물)] - Wadhwa A / 2014 / Evaluation of ethanol vortex ELISA for detection of bovine tuberculosis in cattle and deer / BMC Vet Res 10 : 147 ~
[학술지(정기간행물)] - Waters WR / 2011 / Development and evaluation of an enzyme-linked immunosorbent assay for use in the detection of bovine tuberculosis in cattle / Clin Vaccine Immunol 18 : 1882 ~ 1888
[학술지(정기간행물)] - Schiller I / 2010 / Bovine tuberculosis: a review of current and emerging diagnostic techniques in view of their relevance for disease control and eradication / Transbound Emerg Dis 57 : 205 ~ 220
[학술지(정기간행물)] - Neill SD / 1994 / Detection of Mycobacterium bovis infection in skin test-negative cattle with an assay for bovine interferongamma / Vet Rec 135 : 134 ~ 135
[학술지(정기간행물)] - Wadhwa A / 2014 / Evaluation of ethanol vortex ELISA for detection of bovine tuberculosis in cattle and deer / BMC Vet Res 10 : 147 ~
[학술지(정기간행물)] - Waters WR / 2011 / Development and evaluation of an enzyme-linked immunosorbent assay for use in the detection of bovine tuberculosis in cattle / Clin Vaccine Immunol 18 : 1882 ~ 1888
[학술지(정기간행물)] - Schiller I / 2010 / Bovine tuberculosis: a review of current and emerging diagnostic techniques in view of their relevance for disease control and eradication / Transbound Emerg Dis 57 : 205 ~ 220
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