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자료유형
학술저널
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대한바이러스학회 JOURNAL OF BACTERIOLOGY AND VIROLOGY 大韓바이러스學會誌 제21권 제2호
발행연도
1991.12
수록면
179 - 182 (4page)

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Adenovirus group consists of over 90 related viruses which have been isolated from respiratory or gastro-intestinal tract of primate, cattle, dog and mice. Approximately 40 serologic types of adenovirus producing a variety of human respiratory and conjuntival infections were identified. Adenoviruses are icosahedral virions containing double-strand linea DNA. They are 70 nm to 90 nm in diameter, and each of capsid is composed of 252 capsomeres. Several members of this group, including types commonly associated with respiratory disease in rnan, are capable of producing malignant tumors in young hamsters and a few types have been shown to be oncogenic in young rat. Previous report involving effect of hormone on replication of adenovirus has been carried out. The present report represents a continuation of previous study. To obtain evidence concerning the effect of hormone on the transformation, investigation of adenovirus type 12 of this group was undertaken. For practical consideration it was desirable to investigation of the effect of hormone (estradiol-17 B) on the adenovirus type 12-induced transformation in L cell. Results were as follows ; 1. Adenovirus type 12-induced transformation was inhibited in the presence of estradiole-17B (10 M). 2. Yields of adenovirus type 12 in L cell were slightly inhibited by treatment of estradiol-17B (10 M).

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