지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.6
- 수록면
- 79 - 84 (6page)
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초록· 키워드
오류제보하기
A vitamin B-6 (B-6) intake higher than the current Recommended Dietary Allowance (RDA) has been found to provide an improvement in immune system. Seven premenopausal women consumed their usual diet with the exception of foods relatively high in vitamin B-6 for a total of 27 d. After 7 d, all subjects received a multivitamin supplement containing 2㎎ B-6 and 4 subjects were given an additional 50㎎ of B-6 supplement for 20 d. Lymphocyte response to phytohemagglutinin (PHA) was measured before and after the supplementation. To determine the effect of different forms of B-6 on lymphocyte proliferation, cell culture media supplemented with pyridoxal (PL) and PLP, as well as B-6 free media, were tested. A 50㎎ B-6 supplement significantly increased vitamin B-6 status. There was no further enhancement on lymphocyte proliferation when subjects were taking an additional 50㎎ of vitamin B-6 supplement. In general, lymphocyte proliferation in media with either PLP or PL did not show any prominent difference. These findings suggest that there may be no further benefits of a B-6 dose beyond twice that of the current RDA on lymphocyte proliferation. Further studies are necessary to examine the effect of the B-6 intake level on activities of enzymes involved in cellular B-6 metabolism in lymphocytes to provide substantial insight into the mechanisms underlying the role of B-6 in the lymphocyte proliferation.
목차
ABSTRACT
Introduction
Subjects and Methods
Results
Discussion
References
참고문헌 (20)
참고문헌 신청
[학술지(정기간행물)] - Axelrod AE / 1964 / Relationship of pyridoxine to immunological phenomena : 591 ~ 607
[학술지(정기간행물)] - Baum MK / 1991 / Association of vitamin B6 status with parameters of immune function in early HIV-1 infection : 1122 ~ 1132
[학술지(정기간행물)] - Casciato DA / 1984 / Improvement after pyridoxine therapy : 9 ~ 38 16
[학술지(정기간행물)] - Coburn SP / 1969 / Leukocyte pyridoxal phosphate and alkaline phosphatase in Down’s syndrome and other retardates : 1197 ~ 1203
[학술지(정기간행물)] - Korner WF / 1974 / Vitamin B6 deficiency in uremia and its implications for the depression of immune responses : 233 ~ 239
[학술지(정기간행물)] - Baum MK / 1991 / Association of vitamin B6 status with parameters of immune function in early HIV-1 infection : 1122 ~ 1132
[학술지(정기간행물)] - Casciato DA / 1984 / Improvement after pyridoxine therapy : 9 ~ 38 16
[학술지(정기간행물)] - Coburn SP / 1969 / Leukocyte pyridoxal phosphate and alkaline phosphatase in Down’s syndrome and other retardates : 1197 ~ 1203
[학술지(정기간행물)] - Korner WF / 1974 / Vitamin B6 deficiency in uremia and its implications for the depression of immune responses : 233 ~ 239
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