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자료유형
학술저널
저자정보
Won-Hee Kim (Seoul National University Medical Research Center) Eun-Hee Shin (Seoul National University Bungdang Hospital) Jae-Lip Kim (Seoul National University Medical Research Center) Seung-Young Yu (Kyung Hee University Graduate School of Medicine) Bong-Kwang Jung (Seoul National University Medical Research Center) Jong-Yil Chai (Seoul National University Medical Research Center)
저널정보
대한기생충학열대의학회 Parasites, Hosts and Diseases The Korean Journal of Parasitology Vol.48 No.4
발행연도
2010.12
수록면
325 - 329 (5page)

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Toxoplasma gondii KI-1, a recent new isolate from Korea, shows similar pathogenicity and infectivity to mice compared to the virulent RH strain. To understand characteristics of host immunity, including immune enhancement or suppression, we investigated proliferative responses and phenotypes of spleen cells. In addition, kinetics of IFN-g, a Th1 cytokine, was examined in BALB/c mice up to day 6 post-infection (PI). Intraperitoneal injection of mice with 10³ KI-1 tachyzoites induced significant decreases (P < 0.05) in proliferative responses of spleen cells. This occurred at days 2-6 PI even when concanavalin A (con A) was added and when stimulated with KI-1 antigen, suggesting suppression of the immunity. CD4+ T-cells decreased markedly at day 2 PI (P < 0.05), whereas CD8+ T-cells, NK cells, and macrophages did not show significant changes, except a slight, but significant, increase of CD8+ T-cells at day 6 PI. The capacity of splenocytes to produce IFN-g by con A stimulation dropped significantly at days 2-6 PI. These results demonstrate that intraperitoneal injection of KI-1 tachyzoites can induce immunosuppression during the early stage of infection, as revealed by the decrease of CD4+ T-cells and IFN-g.

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