지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.6
- 수록면
- 115 - 123 (9page)
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초록· 키워드
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Toxoplasma gondii Korean isolate (KI-1) tachyzoites were inoculated intraduodenally to BALB/c mice using a silicon tube, and the course of infection and immune responses of mice were studied. Whereas control mice, that were infected intraperitoneally, died within day 7 post-infection (PI), the intraduodenally infected mice survived until day 9 PI (infection with 1×105 tachyzoites) or day 11 PI (with 1×106 tachyzoites). Based on histopathologic (Giemsa stain) and PCR (B1 gene) studies, it was suggested that tachyzoites, after entering the small intestine, invaded into endothelial cells, divided there, and propagated to other organs. PCR appeared to be more sensitive than histopathology to detect infected organs and tissues. The organisms spread over multiple organs by day 6 PI. However, proliferative responses of splenocytes and mesenteric lymph node (MLN) cells in response to con A or Toxoplasma lysate antigen decreased significantly, suggesting immunosuppression. Splenic CD4+ and CD8+ T-lymphocytes showed decreases in number until day 9 PI, whereas IFN-γ and IL-10 decreased slightly at day 6 PI and returned to normal levels by day 9 PI. No TNF-α was detected throughout the experimental period. The results showed that intraduodenal infection with KI-1 tachyzoites was successful but did not elicit significant mucosal immunity in mice and allowed dissemination of T. gondii organisms to systemic organs. The immunosuppression of mice included reduced lymphoproliferative responses to splenocytes and MLN cells to mitogen and low production of cytokines, such as IFN-γ, TNF-α, and IL-10, in response to T. gondii infection.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Dubey JP / 2008 / Toxoplasma gondii infection in humans and animals in the Unites States / Int J Parasitol 38 : 1257 ~ 1278
2. [학술지(정기간행물)] - Cenci-Goga BT / 2011 / Toxoplasma in animals, food, and humans: an old parasite of new concern / Foodborne Pathog Dis 8 : 1 ~ 12
3. [학술지(정기간행물)] - Pettersen EK / 1979 / Destruction of Toxoplasma gondii by HCl solution / Acta Pathol Microbiol Scand B 87 : 217 ~ 220
4. [학술지(정기간행물)] - Sharma SP / 1981 / Quantitative survival of Toxoplasma gondii tachyzoites and bradyzoites in pepsin and in trypsin solutions / Am J Vet Res 42 : 128 ~ 130
5. [학술지(정기간행물)] - Popiel I / 1996 / Quantification of Toxoplasma gondii bradyzoites / J Parasitol 82 : 330 ~ 332
2. [학술지(정기간행물)] - Cenci-Goga BT / 2011 / Toxoplasma in animals, food, and humans: an old parasite of new concern / Foodborne Pathog Dis 8 : 1 ~ 12
3. [학술지(정기간행물)] - Pettersen EK / 1979 / Destruction of Toxoplasma gondii by HCl solution / Acta Pathol Microbiol Scand B 87 : 217 ~ 220
4. [학술지(정기간행물)] - Sharma SP / 1981 / Quantitative survival of Toxoplasma gondii tachyzoites and bradyzoites in pepsin and in trypsin solutions / Am J Vet Res 42 : 128 ~ 130
5. [학술지(정기간행물)] - Popiel I / 1996 / Quantification of Toxoplasma gondii bradyzoites / J Parasitol 82 : 330 ~ 332
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UCI(KEPA) : I410-ECN-0101-2014-510-002511555