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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.9
- 수록면
- 197 - 204 (8page)
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초록· 키워드
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Trypanosoma brucei, a protozoan parasite, causes sleeping sickness in humans and Nagana disease in domestic animals in central Africa. The trypanosome surface is extensively covered by glycosylphosphatidylinositol (GPI)-anchored proteins known as variant surface glycoproteins and procyclins. GPI anchoring is suggested to be important for trypanosome survival and establishment of infection. Trypanosomes are not only pathogenically important, but also constitute a useful model for elucidating the GPI biosynthesis pathway. This review focuses on the trypanosome GPI biosynthesis pathway. Studies on GPI that will be described indicate the potential for the design of drugs that specifically inhibit trypanosome GPI biosynthesis.
목차
Abstract
INTRODUCTION
GPI BIOSYNTHESIS BY TRYPANOSOMES
CONCLUSION
REFERENCES
참고문헌 (69)
참고문헌 신청
1. [학술지(정기간행물)] - Cross GA / 1996 / Antigenic variation in trypanosomes: secrets surface slowly / Bioessays 18 : 283 ~ 291
2. [학술지(정기간행물)] - Acosta-Serrano A / 2001 / The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly / Proc Natl Acad Sci 98 : 1513 ~ 1518
3. [학술지(정기간행물)] - Ferguson MA / 1988 / Glycosylphosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane / Science 239 : 753 ~ 759
4. [학술지(정기간행물)] - Homans SW / 1988 / Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein / Nature 333 : 269 ~ 272
5. [학술지(정기간행물)] - Field MC / 1991 / A glycosylphosphatidylinositol protein anchor from procyclic stage Trypanosoma brucei: lipid structure and biosynthesis / EMBO J 10 : 2731 ~ 2739
2. [학술지(정기간행물)] - Acosta-Serrano A / 2001 / The surface coat of procyclic Trypanosoma brucei: programmed expression and proteolytic cleavage of procyclin in the tsetse fly / Proc Natl Acad Sci 98 : 1513 ~ 1518
3. [학술지(정기간행물)] - Ferguson MA / 1988 / Glycosylphosphatidylinositol moiety that anchors Trypanosoma brucei variant surface glycoprotein to the membrane / Science 239 : 753 ~ 759
4. [학술지(정기간행물)] - Homans SW / 1988 / Complete structure of the glycosyl phosphatidylinositol membrane anchor of rat brain Thy-1 glycoprotein / Nature 333 : 269 ~ 272
5. [학술지(정기간행물)] - Field MC / 1991 / A glycosylphosphatidylinositol protein anchor from procyclic stage Trypanosoma brucei: lipid structure and biosynthesis / EMBO J 10 : 2731 ~ 2739
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UCI(KEPA) : I410-ECN-0101-2014-510-002539426