지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2013.1
- 수록면
- 94 - 99 (6page)
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초록· 키워드
오류제보하기
Proteinuric conditions demonstrate structural and compositional changes of the foot processes and slit diaphragms between podocytes. p130Cas in podocytes serves as an adapter protein anchoring glomerular basement membrane to actin filaments of podocyte cytoskeleton. To investigate the effect of ginseng total saponin (GTS) on the pathologic changes of podocyte p130Cas induced by diabetic conditions, we cultured mouse podocytes under: 1) normal glucose (5 mM, control); 2) high glucose (HG, 30 mM); 3) advanced glycosylation endproducts (AGE)-added; or 4) HG plus AGE-added conditions and treated with GTS. In confocal imaging, p130Cas colocalized with zonula occludens-1 and synaptopodin connecting to F-actin. However, diabetic conditions relocalized p130Cas molecules at perinuclear cytoplasmic area and reduced the intensity of p130Cas. In Western blotting, diabetic conditions, especially HG plus AGE-added condition, decreased cellular p130Cas protein levels at 24 and 48h. GTS improved such quantitative and qualitative changes. These findings imply that HG and AGE have an influence on the redistribution and amount of p130Cas of podocytes, which can be reversed by GTS.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (31)
참고문헌 신청
1. [단행본] - Parving HH / 2011 / Diabetic nephropathy, In The kidney / WB Saunders : 1411 ~ 1454
2. [학술지(정기간행물)] - Kanwar YS / 2008 / Diabetic nephropathy: mechanisms of renal disease progression / Exp Biol Med (Maywood) 233 : 4 ~ 11
3. [학술지(정기간행물)] - Sharma K / 1997 / Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy / Semin Nephrol 17 : 80 ~ 92
4. [학술지(정기간행물)] - Vlassara H. / 1996 / Protein glycation in the kidney: role in diabetes and aging / Kidney Int 49 : 1795 ~ 1804
5. [학술지(정기간행물)] - Mundel P / 1995 / Structure and function of podocytes: an update / Anat Embryol (Berl) 192 : 385 ~ 397
2. [학술지(정기간행물)] - Kanwar YS / 2008 / Diabetic nephropathy: mechanisms of renal disease progression / Exp Biol Med (Maywood) 233 : 4 ~ 11
3. [학술지(정기간행물)] - Sharma K / 1997 / Biochemical events and cytokine interactions linking glucose metabolism to the development of diabetic nephropathy / Semin Nephrol 17 : 80 ~ 92
4. [학술지(정기간행물)] - Vlassara H. / 1996 / Protein glycation in the kidney: role in diabetes and aging / Kidney Int 49 : 1795 ~ 1804
5. [학술지(정기간행물)] - Mundel P / 1995 / Structure and function of podocytes: an update / Anat Embryol (Berl) 192 : 385 ~ 397
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UCI(KEPA) : I410-ECN-0101-2014-524-000316449