지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.12
- 수록면
- 421 - 428 (8page)
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This study evaluated cholineresterase inhibitory activity of Korean white ginseng extract (WGE), red ginseng extract (RGE), and black ginseng extract (BGE) and the cholinergic effect on scopolamine (SCOP)-induced amnesic mice. WGE, RGE, and BGE inhibited acetylcholineserase (AChE), as well as butyrylcholineserase (BuChE) in a concentration-dependent manner. BGE presented strong inhibition of AChE with an IC<sub>50</sub> value of 1.72 mg/mL, followed by WGE (5.89 mg/mL), RGE (6.30 mg/mL), respectively. The inhibitory activity of the three ginseng extracts on BuChE showed similar values among the groups. To better understand the mechanisms of the possible effect of ginseng extract on the cholinergic function, this study assessed the expression of the cholinergic markers of choline acetyltransferase (ChAT) and AChE using western blot and RT-PCR analysis in the brains of amnesic mice. Treatment with ginseng extracts led to inhibition of AChE expression and, the activation of ChAT expression in the hippocampus and the cerebral cortex of amnesic mice as induced by SCOP. The results suggest that ginseng extracts including BOE, appear to modulate the metabolism of acetylchoine (ACh), which would greatly increase synaptic ACh levels and most potently revert SCOP-induced amnesia.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (24)
참고문헌 신청
1. [학술지(정기간행물)] - Birthelmer A / 2003 / Does the release of acetylcholine in septal slices originate from intrinsic cholinergic neurons bearing p75(NTR) receptors? A study using 192 IgG-saporin lesions in rats / Neuroscience 122 : 1059 ~ 1071
2. [학술지(정기간행물)] - Bartus RT / 2000 / On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis / Exp Neurol 163 : 495 ~ 529
3. [학술지(정기간행물)] - Beatty WW / 1986 / Patterns of memory failure after scopolamine treatment: implications for cholinergic hypotheses of dementia / Behav Neural Biol 45 : 196 ~ 211
4. [학술지(정기간행물)] - Ohno K / 2001 / Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans / Proc Natl Acad Sci U S A 98 : 2017 ~ 2022
5. [학술지(정기간행물)] - Ballard CG / 2005 / Cholinesterases: roles in the brain during health and disease / Curr Alzheimer Res 2 : 307 ~ 318
2. [학술지(정기간행물)] - Bartus RT / 2000 / On neurodegenerative diseases, models, and treatment strategies: lessons learned and lessons forgotten a generation following the cholinergic hypothesis / Exp Neurol 163 : 495 ~ 529
3. [학술지(정기간행물)] - Beatty WW / 1986 / Patterns of memory failure after scopolamine treatment: implications for cholinergic hypotheses of dementia / Behav Neural Biol 45 : 196 ~ 211
4. [학술지(정기간행물)] - Ohno K / 2001 / Choline acetyltransferase mutations cause myasthenic syndrome associated with episodic apnea in humans / Proc Natl Acad Sci U S A 98 : 2017 ~ 2022
5. [학술지(정기간행물)] - Ballard CG / 2005 / Cholinesterases: roles in the brain during health and disease / Curr Alzheimer Res 2 : 307 ~ 318
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UCI(KEPA) : I410-ECN-0101-2013-524-001212584