지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 352 - 359 (8page)
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초록· 키워드
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Korean red ginseng (KRG) is used worldwide as a popular traditional herbal medicine. KRG has shown beneficial effects on cardiovascular diseases, such as atherosclerosis, diabetes, and hypertension. Up-regulation of a cytoprotective protein, heme oxygenase (HO)-1, is considered to augment the cellular defense against various agents that may induce cytotoxic injury. In the present study, we demonstrate that KRG water extract induces HO-1 expression in human umbilical vein endothelial cells (HUVECs) and possible involvement of the anti-oxidant transcription factor nuclear factor-eythroid 2-related factor 2 (Nrf2). KRG-induced HO-1 expression was examined by western blots, reverse transcriptase polymerase chain reaction and immunofluorescence staining. Specific silencing of Nrf2 genes with Nrf2-siRNA in HUVECs abolished HO-1 expression. In addition, the HO inhibitor zinc protoporphyrin blunted the preventive effect of KRG on H<sub>2</sub>O<sub>2</sub>-induced cell death, as demonstrated by terminal transferase dUTP nick end labeling assay. Taken together, these results suggest that KRG may exert a vasculoprotective effect through Nrf2-mediated HO-1 induction in human endothelial cell by inhibition of cell death.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (41)
참고문헌 신청
1. [학술지(정기간행물)] - Sumpio BE / 2002 / Cells in focus: endothelial cell / Int J Biochem Cell Biol 34 : 1508 ~ 1512
2. [학술지(정기간행물)] - Ip JH / 1990 / Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation / J Am Coll Cardiol 15 : 1667 ~ 1687
3. [학술지(정기간행물)] - Byung-Jae Park / 2009 / Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage / BMB reports 42 (8) : 500 ~ 505
4. [학술지(정기간행물)] - Jin YR / 2007 / Antithrombotic and antiplatelet activities of Korean red ginseng extract / BASIC CLINICAL PHARMACOLOGY TOXICOLOGY 100 (3) : 170 ~ 175
5. [학술지(정기간행물)] - Kwak YS / 2010 / Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng / Biol Pharm Bull 33 : 468 ~ 472
2. [학술지(정기간행물)] - Ip JH / 1990 / Syndromes of accelerated atherosclerosis: role of vascular injury and smooth muscle cell proliferation / J Am Coll Cardiol 15 : 1667 ~ 1687
3. [학술지(정기간행물)] - Byung-Jae Park / 2009 / Anti-oxidative effects of Phellinus linteus and red ginseng extracts on oxidative stress-induced DNA damage / BMB reports 42 (8) : 500 ~ 505
4. [학술지(정기간행물)] - Jin YR / 2007 / Antithrombotic and antiplatelet activities of Korean red ginseng extract / BASIC CLINICAL PHARMACOLOGY TOXICOLOGY 100 (3) : 170 ~ 175
5. [학술지(정기간행물)] - Kwak YS / 2010 / Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng / Biol Pharm Bull 33 : 468 ~ 472
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UCI(KEPA) : I410-ECN-0101-2013-524-000762283