지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Objectives: This study investigated the effect of Yukmijihwangtang on cerebral ischemia-induced learning and memory impairment by middle cerebral artery (MCA) occlusion in rats.
Methods: The ability of learning and memory of rats was measured using the eight-arm radial maze and the passive avoidance test, and profile of cholinergic neuron was assessed in the medial septum and hippocampus region by immuno-histochemistry.
Results: 1. No differences were found between groups in the number of correct choices in acquisition performance during the eight-arm radial maze task.
2. No differences were found between groups on day 1 in the error rate in acquisition performance, which is defined as the number of enters into the same arm more than once within five minutes. After 5 to 6 days of test, the number of errors was significantly reduced in the Yukmijihwangtang group (forebrain ischemia group with Yukmijihwangtang treatment), compared with the ischemia group.
3. The memory processes significantly improved in the Yukmijihwangtang group according to results of the passive avoidance test.
4. The appearance of AchE (acetylcholinesterase) in the CA1 region of hippocampus significantly decreased in the ischemia group, compared with the sham group (untreated group). The appearance of AchE in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group.
5. The appearance of ChAT (choline acetyltransferase) in the CA1 region of the hippocampus and medial septum decreased in the ischemia group, compared with the sham group. The appearance of ChAT in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group
Conclusions: This study provides evidence that Yukmijihwangtang is effective for reviving the ability of learning and memory and damaged neurons in rats with experimental cerebral ischemia.
Methods: The ability of learning and memory of rats was measured using the eight-arm radial maze and the passive avoidance test, and profile of cholinergic neuron was assessed in the medial septum and hippocampus region by immuno-histochemistry.
Results: 1. No differences were found between groups in the number of correct choices in acquisition performance during the eight-arm radial maze task.
2. No differences were found between groups on day 1 in the error rate in acquisition performance, which is defined as the number of enters into the same arm more than once within five minutes. After 5 to 6 days of test, the number of errors was significantly reduced in the Yukmijihwangtang group (forebrain ischemia group with Yukmijihwangtang treatment), compared with the ischemia group.
3. The memory processes significantly improved in the Yukmijihwangtang group according to results of the passive avoidance test.
4. The appearance of AchE (acetylcholinesterase) in the CA1 region of hippocampus significantly decreased in the ischemia group, compared with the sham group (untreated group). The appearance of AchE in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group.
5. The appearance of ChAT (choline acetyltransferase) in the CA1 region of the hippocampus and medial septum decreased in the ischemia group, compared with the sham group. The appearance of ChAT in the same region significantly increased in the Yukmijihwangtang group, compared with the ischemia group
Conclusions: This study provides evidence that Yukmijihwangtang is effective for reviving the ability of learning and memory and damaged neurons in rats with experimental cerebral ischemia.
목차
서론
재료 및 방법
결과
고찰
결론
참고문헌
참고문헌 (63)
참고문헌 신청
1. [학술지(정기간행물)] - Siesjo,B.K. / 1984 / Cerebral circulation and metabolism / J neurosurg 60 : 883 ~ 908
2. [학술지(정기간행물)] - Winn,R.H. / 1980 / Changes in brain adenosine during bicucullinginduced seizures in rat. Effects hypoxia and altered systemic blood pressure / Circ Res 47 : 568 ~ 577
3. [학술지(정기간행물)] - Zetterstorm, T. / 1982 / Purine levels the intact rat brain. Studies with an implanted perfused hollow fibet / Neurosci lett 29 : 111 ~ 115
4. [학술지(정기간행물)] - Petito,C. K. / 1987 / Delayed hippocampal damage in humans following cardiorespiratory arrest / Neurology 37 : 1281 ~ 1286
5. [학술지(정기간행물)] - Lee YS / 1998 / Neuroprotective Effects of Lamotrigine in Transient Global Ischemia / Journal of the Korean Neurological Association 16 (2) : 113 ~ 118
2. [학술지(정기간행물)] - Winn,R.H. / 1980 / Changes in brain adenosine during bicucullinginduced seizures in rat. Effects hypoxia and altered systemic blood pressure / Circ Res 47 : 568 ~ 577
3. [학술지(정기간행물)] - Zetterstorm, T. / 1982 / Purine levels the intact rat brain. Studies with an implanted perfused hollow fibet / Neurosci lett 29 : 111 ~ 115
4. [학술지(정기간행물)] - Petito,C. K. / 1987 / Delayed hippocampal damage in humans following cardiorespiratory arrest / Neurology 37 : 1281 ~ 1286
5. [학술지(정기간행물)] - Lee YS / 1998 / Neuroprotective Effects of Lamotrigine in Transient Global Ischemia / Journal of the Korean Neurological Association 16 (2) : 113 ~ 118
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UCI(KEPA) : I410-ECN-0101-2014-519-000284392