지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives : Hwangryunhaedok-tang (HRHDT), a prescription composed of four herbs, has been wi dely used in Oriental Medicine for the treatment of cerebral infarction. However, the mechanisms by which the herbal formula affects on the production of pro- and anti-inflammatory cytokines in cerebral infarction patients remain unknown yet.
Methods : The levels of pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-a, interleukin (IL)-1b, and IL-6, IL-10, and TGF-β1 were determined in peripheral blood mononuclear cells (PBMCs) from cerebral infarction patients under our experimental conditions.
Results : The secretory levels of pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-a, interleukin (IL)-1b, and IL-6, and IL-10 were significantly increased in phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from cerebral infarction patients. However, pretreatment with HRHDT significantly inhibited the secretion of pro- and anti-inflammatory in PBMCs. Also, HRHDT induced a significant increase of transforming growth factor (TGF)-b1 in PBMCs.
Conclusions : These data indicate that HRHDT may be beneficial in the suppression of inflammatory processes of cerebral infarct through suppression of TNF-α, IL-1β, IL-6, and IL-10 and induction of TGF-β1.
Methods : The levels of pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-a, interleukin (IL)-1b, and IL-6, IL-10, and TGF-β1 were determined in peripheral blood mononuclear cells (PBMCs) from cerebral infarction patients under our experimental conditions.
Results : The secretory levels of pro- and anti-inflammatory cytokines, including tumor necrosis factor (TNF)-a, interleukin (IL)-1b, and IL-6, and IL-10 were significantly increased in phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from cerebral infarction patients. However, pretreatment with HRHDT significantly inhibited the secretion of pro- and anti-inflammatory in PBMCs. Also, HRHDT induced a significant increase of transforming growth factor (TGF)-b1 in PBMCs.
Conclusions : These data indicate that HRHDT may be beneficial in the suppression of inflammatory processes of cerebral infarct through suppression of TNF-α, IL-1β, IL-6, and IL-10 and induction of TGF-β1.
목차
Introduction
Materials and Methods
Results
Discussion
Acknowledgement
References
참고문헌 (38)
참고문헌 신청
1. [학술지(정기간행물)] - 백상인 / 2008 / PMA와 A23187로 자극된 RBL-2H3 세포에 미치는 黃連解毒湯의 영향 / 동의생리병리학회지 22 (3) : 600 ~ 606
2. [학술지(정기간행물)] - 문진영 / 2007 / 黃連解毒湯의 산화적 DNA 손상에 대한 보호효과 및 항산화효소계의 발현과 Acetylcholinesterase 활성에 미치는 영향 / 대한본초학회지 22 (1) : 7 ~ 12
3. [학술지(정기간행물)] - 안상훈 / 2006 / 黃連解毒湯이 Hypoxia-reoxygenation에 의해 손상 받은 Mouse Neuroblastoma 2a Cells에 미치는 影響 / 동의신경정신과학회지 17 (2) : 37 ~ 59
4. [학술지(정기간행물)] - 김혜윤 / 2008 / Glucose-deprivation으로 유발된 PC-12 cell의 세포 고사에 대한 黃連解毒湯의 보호 효과 / 동의생리병리학회지 22 (6) : 1462 ~ 1469
5. [학술지(정기간행물)] - Bémeur C / 2005 / Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat / Neurochem Int 46 : 399 ~ 407
2. [학술지(정기간행물)] - 문진영 / 2007 / 黃連解毒湯의 산화적 DNA 손상에 대한 보호효과 및 항산화효소계의 발현과 Acetylcholinesterase 활성에 미치는 영향 / 대한본초학회지 22 (1) : 7 ~ 12
3. [학술지(정기간행물)] - 안상훈 / 2006 / 黃連解毒湯이 Hypoxia-reoxygenation에 의해 손상 받은 Mouse Neuroblastoma 2a Cells에 미치는 影響 / 동의신경정신과학회지 17 (2) : 37 ~ 59
4. [학술지(정기간행물)] - 김혜윤 / 2008 / Glucose-deprivation으로 유발된 PC-12 cell의 세포 고사에 대한 黃連解毒湯의 보호 효과 / 동의생리병리학회지 22 (6) : 1462 ~ 1469
5. [학술지(정기간행물)] - Bémeur C / 2005 / Dehydroascorbic acid normalizes several markers of oxidative stress and inflammation in acute hyperglycemic focal cerebral ischemia in the rat / Neurochem Int 46 : 399 ~ 407
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UCI(KEPA) : I410-ECN-0101-2014-519-000282161