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논문 기본 정보
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- 학술저널
- 저자정보
- 발행연도
- 2008.3
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- 29 - 37 (9page)
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Interleukin-23 (IL-23) is a novel pro-inflammatory cytokine which has been implicated to play a pathogenic role in rheumatoid arthritis (RA). This study was undertaken to investigate the IL-23 inductive activity of the proinflammatory cytokine IL-17, IL-1β and tumor necrosis factor (TNF-α) in RA synovial fluid mononuclear cells (SFMC). Expression of IL-23p19, IL-17, IL-1β and TNF-α in joint was examined by immunohistochemistry (IHC) of patients with RA and osteoarthritis (OA). The effects of IL-17 and IL-1β on expression of IL-23p19 in human SFMC from RA patients were determined by reverse transcriptase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay (ELISA). IL-23p19 was expressed in the RA fibroblast like synoviocyte (FLS), but not from OA FLS. Similar to the protein expression, IL-23p19 mRNA could be detected by RT-PCR in RA SFMC. IL-17 and IL-1β could induce RA SFMC to produce the IL-23p19. The effects of IL-17 were much stronger than IL-1β or TNF-α. These responses were observed in a doseresponsive manner. In addition, IL-17 or IL-1β neutralizing antibody down-regulated the expression of IL-23p19 induced by LPS in RA-SFMC. Our results demonstrate that IL-23p19 is overexpressed in RA synovium and IL-17 and IL-1β appears to upregulate the expression of IL-23p19 in RA-SFMC.
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참고문헌 (35)
참고문헌 신청
1. [학술지(정기간행물)] - Goldring SR / 2003 / Pathogenesis of bone and cartilage destruction in rheumatoid arthritis / Rheumatology 42 : 11 ~ 16
2. [학술지(정기간행물)] - Harris ED, Jr / 1990 / Rheumatoid arthritis. Pathophysiology and implications for therapy / N Engl J Med 322 : 1277 ~ 1289
3. [학술지(정기간행물)] - Miossec P / 2004 / An update on the cytokine network in rheumatoid arthritis / Curr Opin Rheumatol 16 : 218 ~ 222
4. [학술지(정기간행물)] - Chabaud M / 1999 / Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium / Arthritis Rheum 42 : 963 ~ 970
5. [학술지(정기간행물)] - Sato K / 2006 / Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction / J Exp Med 203 : 2673 ~ 2682
2. [학술지(정기간행물)] - Harris ED, Jr / 1990 / Rheumatoid arthritis. Pathophysiology and implications for therapy / N Engl J Med 322 : 1277 ~ 1289
3. [학술지(정기간행물)] - Miossec P / 2004 / An update on the cytokine network in rheumatoid arthritis / Curr Opin Rheumatol 16 : 218 ~ 222
4. [학술지(정기간행물)] - Chabaud M / 1999 / Human interleukin-17: a T cell-derived proinflammatory cytokine produced by the rheumatoid synovium / Arthritis Rheum 42 : 963 ~ 970
5. [학술지(정기간행물)] - Sato K / 2006 / Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction / J Exp Med 203 : 2673 ~ 2682
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