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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.3
- 수록면
- 17 - 22 (6page)
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초록· 키워드
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Objectives：Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by abnormalities of social functioning, communication and behavior. The association of the 7q21-34 region with ASD has been reported. The DLX6 gene, which is located at the 7q22 region, is one of the positional and functional candidate genes for ASD. We found that there is no association between DLX6 polymorphisms and ASD in the Korean male population.
Methods：We selected three single nucleotide polymorphisms (SNPs) that might be implicated in the change of the DLX6 gene expression. The genomic DNA was collected from the venous blood of 147 male controls and 179 male patients with ASD. The genotypes of the selected SNPs were determined using the Illumina GoldenGate assay, and the statistical analyses were performed using HapAnalyzer software and SAS Enterprise.
Results：We found no association of the three SNPs in the DLX6 gene with ASD in the Korean male population.
Conclusion：Our study suggests that the three SNPs in the DLX6 gene are not associated with ASD, and we need to analyze the previously reported regions for their associations with ASD.
Methods：We selected three single nucleotide polymorphisms (SNPs) that might be implicated in the change of the DLX6 gene expression. The genomic DNA was collected from the venous blood of 147 male controls and 179 male patients with ASD. The genotypes of the selected SNPs were determined using the Illumina GoldenGate assay, and the statistical analyses were performed using HapAnalyzer software and SAS Enterprise.
Results：We found no association of the three SNPs in the DLX6 gene with ASD in the Korean male population.
Conclusion：Our study suggests that the three SNPs in the DLX6 gene are not associated with ASD, and we need to analyze the previously reported regions for their associations with ASD.
목차
서론
방법
결과
고찰
결론
References
참고문헌 (37)
참고문헌 신청
1. [학술지(정기간행물)] - Gillberg C / 1999 / Autism: not an extremely rare disorder / Acta Psychiatr Scand 99 : 399 ~ 406
2. [학술지(정기간행물)] - Fombonne E / 1999 / The epidemiology of autism: a review / Psychol Med 29 : 769 ~ 786
3. [학술지(정기간행물)] - Kaminsky Z / 2006 / Complex disease, gender and epigenetics / Ann Med 38 : 530 ~ 544
4. [학술지(정기간행물)] - Folstein S / 1977 / Genetic influences and infantile autism / Nature 265 : 726 ~ 728
5. [학술지(정기간행물)] - Folstein S / 1977 / Infantile autism: a genetic study of 21 twin pairs / J Child Psychol Psychiatry 18 : 297 ~ 321
2. [학술지(정기간행물)] - Fombonne E / 1999 / The epidemiology of autism: a review / Psychol Med 29 : 769 ~ 786
3. [학술지(정기간행물)] - Kaminsky Z / 2006 / Complex disease, gender and epigenetics / Ann Med 38 : 530 ~ 544
4. [학술지(정기간행물)] - Folstein S / 1977 / Genetic influences and infantile autism / Nature 265 : 726 ~ 728
5. [학술지(정기간행물)] - Folstein S / 1977 / Infantile autism: a genetic study of 21 twin pairs / J Child Psychol Psychiatry 18 : 297 ~ 321
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UCI(KEPA) : I410-ECN-0101-2014-516-000731240