지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 31 - 36 (6page)
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초록· 키워드
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Dlx3 and Dlx5 are homeobox domain proteins and are well-known regulators of osteoblastic differentiation. Since possible reciprocal relationships between osteogenic and adipogenic differentiation in mesenchymal stem cells exist,we examined the regulatory role of Dlx3 and Dlx5 on adipogenic differentiation using human dental pulp stem cells. Over-expression of Dlx3 and Dlx5 stimulated osteogenic differentiation but inhibited adipogenic differentiation of human dental pulp stem cells. Dlx3 and Dlx5 suppressed the expression of adipogenic marker genes such as C/EBPα,PPARγ, aP2 and lipoprotein lipase. Adipogenic stimuli suppressed the mRNA levels of Dlx3 and Dlx5, whereas osteogenic stimuli enhanced the expression of Dlx3 and Dlx5in 3T3-L1 preadipocytes. These results suggest that Dlx3 and Dlx5 exert a stimulatory effect on osteogenic differentiation of stem cells through the inhibition of adipogenic differentiation as well as direct stimulation.
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참고문헌 (23)
참고문헌 신청
Acampora D / 1999 / Craniofacial, vestibular and bone defects in mice lacking the Distal-less-related gene Dlx5 / Development (Cambridge, England) 126 : 3795 ~ 3809
Ghanem N / 2003 / Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters / Genome Res 13 : 533 ~ 543
Gronthos S / 2000 / Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo / Proc Natl Acad Sci U S A 97 : 13625 ~ 13630
Hassan MQ / 2004 / Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteoc
Hassan MQ / 2006 / BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network / J Biol Chem 281 : 40515 ~ 40526
Ghanem N / 2003 / Regulatory roles of conserved intergenic domains in vertebrate Dlx bigene clusters / Genome Res 13 : 533 ~ 543
Gronthos S / 2000 / Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo / Proc Natl Acad Sci U S A 97 : 13625 ~ 13630
Hassan MQ / 2004 / Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteoc
Hassan MQ / 2006 / BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network / J Biol Chem 281 : 40515 ~ 40526
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