지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.7
- 수록면
- 277 - 290 (14page)
이용수
초록· 키워드
오류제보하기
The metabolic profiles of Panax quinquefolius and its associated therapeutic values are critically affected by the repetitious steaming times. The times-dependent steaming effect of P. quinquefolius is not well-characterized and there is also no official guidelilne on its times of steaming, In this paper, a UPLC-Q-TOF-MS/MS method was developed for the qualitative profiling of multi-parametric metabolic changes of raw P. quinquefolius durilng the repetitious steaming process. Our method was successful in discriminating the differentially multi-steamed herbs. Meantime, the repetitious steaming-inducing chemical transformations in the preparation of black American ginseng (American ginseng that was subjected to 9 cycles of steaming treatment) were evaluated by this UPLC-Q-TOF-MS/MS based chemical profiling method. Under the optimized UPLC-Q-TOF-MS/MS conditions, 29 major ginsenosides were unambiguously identified and/or tentatively assigned in both raw and multi-steamed P. quinquefolius within 19 min, among them 18 ginsenosides were detected to bo newly generated during the preparatory process of black American ginseng. The mechanisms involved were further deduced to be hydrolysis, dehydration, decarboxylation and addition reactions of the original ginsenosiders in raw P. quinquefolius through analyzing 9 cycles of steaming extracts of 14 pure reference ginsenosides. Our novel steaming times-dependent metabolic profiling represents the paradigm shift in the global quality control of multi-steamed P. quinquefolius products.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (43)
참고문헌 신청
1. [단행본] - Chinese Pharmacopeia Commission / 2010 / Pharmacopeia of the People’s Republic of China 2010. Vol. 1 / China Medical Science Publisher
2. [학술지(정기간행물)] - Chun-Su Yuan / 2010 / Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng / Journal of Ginseng Research 34 (3) : 160 ~ 167
3. [학술지(정기간행물)] - Li B / 2010 / Antioxidants potentiate Amellrican ginseng-induced killing of colorectal cancer cells / Cancer Lett 289 : 62 ~ 70
4. [학술지(정기간행물)] - Hai Dan Yuan / 2011 / Anti-Diabetic Effect of Pectinase-Processed Ginseng Radix (GINST) in High Fat Diet-Fed ICR Mice / Journal of Ginseng Research 35 (3) : 308 ~ 314
5. [학술지(정기간행물)] - Chu SF / 2009 / New achievements in ginseng research and its future prospects / Chin J Integr Med 15 : 403 ~ 408
2. [학술지(정기간행물)] - Chun-Su Yuan / 2010 / Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng / Journal of Ginseng Research 34 (3) : 160 ~ 167
3. [학술지(정기간행물)] - Li B / 2010 / Antioxidants potentiate Amellrican ginseng-induced killing of colorectal cancer cells / Cancer Lett 289 : 62 ~ 70
4. [학술지(정기간행물)] - Hai Dan Yuan / 2011 / Anti-Diabetic Effect of Pectinase-Processed Ginseng Radix (GINST) in High Fat Diet-Fed ICR Mice / Journal of Ginseng Research 35 (3) : 308 ~ 314
5. [학술지(정기간행물)] - Chu SF / 2009 / New achievements in ginseng research and its future prospects / Chin J Integr Med 15 : 403 ~ 408
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UCI(KEPA) : I410-ECN-0101-2013-524-003639925