지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.9
- 수록면
- 308 - 314 (7page)
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초록· 키워드
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In the present study, we investigate anti-diabetic effect of pectinase-processed ginseng radix (GINST) in high fat diet-fed ICR mice. The ICR mice were divided into three groups: regular diet group, high fat diet control group (HFD), and GINST-treated group. To induce hyperglycemia, mice were fed a high fat diet for 10 weeks, and mice were administered with 300 mg/kg of GINST once a day for 5 weeks. Oral glucose tolerance test revealed that GINST improved glucose tolerance after glucose challenge. Compared to the HFD control group, fasting blood glucose and insulin levels were decreased by 57.8% (p<0.05) and 30.9% (p<0.01) in GINST-treated group, respectively. With decreased plasma glucose and insulin levels, the insulin resistance index of the GINST-treated group was reduced by 68.1% (p<0.01) compared to the HFD control group. Pancreas of GINST-treated mice preserved a morphological integrity of islets and consequently having more insulin contents. In addition, GINST up-regulated the levels of phosphorylated AMP-activated protein kinase (AMPK) and its target molecule, glucose transporter 4 (GLUT4) protein expression in the skeletal muscle. Our results suggest that GINST ameliorates a hyperglycemia through activation of AMPK/GLUT4 signaling pathway, and has a therapeutic potential for type 2 diabetes.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (29)
참고문헌 신청
1. [학술지(정기간행물)] - Zhiyong Liao / 2010 / Antidiabetic Effect of Flavones from Cirsium japonicum DC in Diabetic Rats / Archives of Pharmacal Research 33 (3) : 353 ~ 362
2. [학술지(정기간행물)] - Zhu CF / 2010 / Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes / Nutrition 26 : 1014 ~ 1020
3. [학술지(정기간행물)] - Gabir MM / 2000 / Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes / Diabetes Care 23 : 1113 ~ 1118
4. [학술지(정기간행물)] - Wang ZQ / 2011 / Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice / J Nutr Biochem
5. [학술지(정기간행물)] - Abdul-Ghani MA / 2010 / Pathogenesis of insulin resistance in skeletal muscle / J Biomed Biotechnol 2010 : 476279 ~
2. [학술지(정기간행물)] - Zhu CF / 2010 / Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes / Nutrition 26 : 1014 ~ 1020
3. [학술지(정기간행물)] - Gabir MM / 2000 / Plasma glucose and prediction of microvascular disease and mortality: evaluation of 1997 American Diabetes Association and 1999 World Health Organization criteria for diagnosis of diabetes / Diabetes Care 23 : 1113 ~ 1118
4. [학술지(정기간행물)] - Wang ZQ / 2011 / Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice / J Nutr Biochem
5. [학술지(정기간행물)] - Abdul-Ghani MA / 2010 / Pathogenesis of insulin resistance in skeletal muscle / J Biomed Biotechnol 2010 : 476279 ~
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UCI(KEPA) : I410-ECN-0101-2013-524-000762223