지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.7
- 수록면
- 256 - 262 (7page)
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초록· 키워드
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Reactive oxygen species play critical role in kidney damage. Free radical-scavenging activities of Panax ginseng are know to be increased by heat-processing. The structural change of ginsenoside and the generation of Maillard reaction products (MRPs) are closely related to the increased free radical-scavenging activities. In the present study, we have demonstrated the Maillard reaction model experiment using ginsenoside Re and glycine mixture to identify the renoprotective effect of MRPs from ginseng or ginsenosides. Ginsenoside Re was transformed into less-polar ginsenosides, namely Rg2, Rg6 and F4 by heat-processing. The free radical-scavenging activity of ginsenoside Re-glycine mixture was increased in temperature-dependant manner by heatprocessing, The improved free radical-scavenging activity by heat-processing was mediated by the generation of antioxidant MRPs which led to the protection of LLC-PK1 renal epithelial cells from oxidative stress. Although the free radical scavenging activities of less-polor ginsenosides were weak, they could protect LLC-PK1 cells from oxidative stress. Therefore, MRPs and less-polar ginsenosides contributed to the combined renoprotective effects against oxidative renal damage.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
ACKNOWLEDGEMENTS
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - 금영삼 / 2000 / Antioxidant and anti-tumor promoting activities of the methanol extract of heat-processed ginseng / CANCER LETTERS 150 : 41 ~ 48
2. [학술지(정기간행물)] - Kim WY / 2000 / Steaming of ginseng at high temperature enhances biological activity / J Nat Prod 63 : 1702 ~ 1704
3. [학술지(정기간행물)] - Hyoung Do Kim / 2010 / Effect of Korean Red Ginseng Extract on Cell Death Responses in Peroxynitrite-Treated Keratinocytes / Journal of Ginseng Research 34 (3) : 205 ~ 211
4. [학술지(정기간행물)] - Kang KS / 2007 / ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C A Meyer / Biol Pharm Bull 30 : 917 ~ 921
5. [학술지(정기간행물)] - Noriko Yamabe / 2011 / The Chemical and 1,1-Diphenyl-2-Picrylhydrazyl Radical Scavenging Activity Changes of Ginsenosides Rb_1 and Rg_1 by Maillard Reaction / Journal of Ginseng Research 35 (1) : 60 ~ 68
2. [학술지(정기간행물)] - Kim WY / 2000 / Steaming of ginseng at high temperature enhances biological activity / J Nat Prod 63 : 1702 ~ 1704
3. [학술지(정기간행물)] - Hyoung Do Kim / 2010 / Effect of Korean Red Ginseng Extract on Cell Death Responses in Peroxynitrite-Treated Keratinocytes / Journal of Ginseng Research 34 (3) : 205 ~ 211
4. [학술지(정기간행물)] - Kang KS / 2007 / ESR study on the structure and hydroxyl radical-scavenging activity relationships of ginsenosides isolated from Panax ginseng C A Meyer / Biol Pharm Bull 30 : 917 ~ 921
5. [학술지(정기간행물)] - Noriko Yamabe / 2011 / The Chemical and 1,1-Diphenyl-2-Picrylhydrazyl Radical Scavenging Activity Changes of Ginsenosides Rb_1 and Rg_1 by Maillard Reaction / Journal of Ginseng Research 35 (1) : 60 ~ 68
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UCI(KEPA) : I410-ECN-0101-2013-524-003639894