고욤 잎 추출물의 항산화 활성 및 적혈구 산화적 손상에 대한 보호 효과

김현수; 강현주; 전인화; 목지예; 박용균; 신준호; 김장호; 장선일

doi:10.15188/kjopp.2013.10.27.5.631

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자료유형: 학술저널

저자정보: 김현수 (아토큐엔에이) 강현주 (전주대학교) 전인화 (아토큐엔에이) 목지예 (전주대학교) 박용균 (아토큐엔에이) 신준호 (아토큐엔에이) 김장호 (호남지역사업평가원) 장선일 (아토큐엔에이)

저널정보: 한의병리학회 동의생리병리학회지 동의생리병리학회지 제27권 제5호

발행연도: 2013.10

수록면: 631 - 636 (6page)

DOI: 10.15188/kjopp.2013.10.27.5.631

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This study was to evaluate the antioxidant properties of the leaf extracts of Diospyros lotus (DLE) on the chemical-induced free radical and rat red blood cell (RBC) oxidative damage in vitro. DLE were prepared by extracting with water. DLE showed the high antioxidant activities on the scavenging of 2,2-diphenyl-1-picrylhydrazyl and 2,2’-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid)-induced radicals. An antioxidant activities of DLE was similar to the reference antioxidant butylated hydroxytoluene (BHT) and (±)6-hydroxy-2,5,7,8-tetramethylchromane-2-carboxylic acid (Trolox). Reducing power of 1,000 μg/mL DLE also was similar to the vitamin C. In RBC, oxidative hemolysis induced by the aqueous peroxyl radical generator (2,2"-Azobis (2-methylpropionamidine) dihydrochloride (AAPH)) were significantly suppressed by DLE in a dose-dependent manner. Furthermore, DLE prevented the depletion of cytosolic antioxidant glutathione in RBC damaged with AAPH. These results suggest that DLE may has value as natural product with its high quality antioxidant properties against oxidative stress.

#Diospyros lotus #water extract #oxidative stress #antioxidant properties

참고문헌 (24)

참고문헌 신청

1. [학술지(정기간행물)] - Shiva Shankar Reddy, C. S. / 2007 / In vitro models of oxidative stress in rat erythrocytes: effect of antioxidant supplements / Toxicol In Vitro 21 : 1355 ~ 1364

2. [학술지(정기간행물)] - Choi, B. M. / 2002 / Nitric oxide as a pro-apoptotic as well as anti-apoptotic modulator / J Biochem Mol Biol 35 : 116 ~ 216

3. [학술지(정기간행물)] - Akhtar, U. S. / 2010 / Cytotoxic and proinflammatory effects of ambient and source-related particulate matter (PM) in relation to the production of reactive oxygen species (ROS) and cytokine adsorption by particles / Inhal Toxicol 2 : 37 ~ 47

4. [학술지(정기간행물)] - Wiseman, H. / 1996 / Dietary influences on membrane function； impotent in protection against oxidative damage and disease / J Nutr Biochem 7 : 2 ~ 15

5. [학술지(정기간행물)] - Park, S.N. / 1997 / Skin Aging and Antioxidant / J Soc Cosmet Scientists Korea 23 : 75 ~

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