지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.3
- 수록면
- 177 - 183 (7page)
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이 논문의 연구 히스토리 (3)
2007
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Purpose: Occult papillary thyroid carcinomas (OPC) are defined as tumors measuring ≤15 ㎜ in size. They are believed to be a less aggressive subset of papillary cancers, which behave more like benign lesions, and are often treated more conservatively. However, some groups have reported a high incidence of metastases from papillary microcarcinomas and favor an aggressive surgical resection followed by radioiodine therapy. We review our experience in an attempt to characterize the biology and optimal treatment for OPCs.
Methods: From October 2001 to March 2006, among impalpable thyroid nodules detected incidentally during screening exams, 214 patients underwent surgery for occult papillary thyroid cancer (OPC) at Kangnam Cha University hospital. The data from these patients were analyzed retrospectively. The mean follow up period was 19.9±11.7 (max：53, min：1) months.
Results: The mean age of these patients was 41.4 year, and 188 (87.7%) were female. 41% of the patients underwent a total or neartotal thyroidectomy, 42% had a central lymph node dissection and 41% had radioiodine ablation therapy after surgery. Of the 214 patients, 40 (18.7%) had lymph node metastases. The LN metastases were associated with the tumor size (P=0.0007), extracapsular invasion (P=0.0268) and multifocality (P=0.0024), but there was no association with age and gender. The incidence of the LN metastases (20%) and extracapsular invasion (59.1%) were higher in the tumors between 0.5∼1.0 ㎝ in size. With a follow-up up to 53 months, 3 patients had a local recurrence (0.014%) but no patients currently has active disease. No patients with OPC died died during this period.
Conclusion: In OPC patients, a progressively increasing frequency of signs of tumor aggressiveness with increasing tumor size was observed but a small size itself could not guarantee a low risk or low recurrence rate. The prevalence of LN metastases and extracapsular invasion were higher in tumors ＞0.5 ㎝ in size. Therefore, we prefer near-total or total thyroidectomy with central lymph node dissection. Early detection and treatment of OPC might be warranted by the routine use of thyroid USG and USG-guided FNA.
Methods: From October 2001 to March 2006, among impalpable thyroid nodules detected incidentally during screening exams, 214 patients underwent surgery for occult papillary thyroid cancer (OPC) at Kangnam Cha University hospital. The data from these patients were analyzed retrospectively. The mean follow up period was 19.9±11.7 (max：53, min：1) months.
Results: The mean age of these patients was 41.4 year, and 188 (87.7%) were female. 41% of the patients underwent a total or neartotal thyroidectomy, 42% had a central lymph node dissection and 41% had radioiodine ablation therapy after surgery. Of the 214 patients, 40 (18.7%) had lymph node metastases. The LN metastases were associated with the tumor size (P=0.0007), extracapsular invasion (P=0.0268) and multifocality (P=0.0024), but there was no association with age and gender. The incidence of the LN metastases (20%) and extracapsular invasion (59.1%) were higher in the tumors between 0.5∼1.0 ㎝ in size. With a follow-up up to 53 months, 3 patients had a local recurrence (0.014%) but no patients currently has active disease. No patients with OPC died died during this period.
Conclusion: In OPC patients, a progressively increasing frequency of signs of tumor aggressiveness with increasing tumor size was observed but a small size itself could not guarantee a low risk or low recurrence rate. The prevalence of LN metastases and extracapsular invasion were higher in tumors ＞0.5 ㎝ in size. Therefore, we prefer near-total or total thyroidectomy with central lymph node dissection. Early detection and treatment of OPC might be warranted by the routine use of thyroid USG and USG-guided FNA.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (26)
참고문헌 신청
Gharib H , 1994 , Fine needle aspiration biopsy of thyroid nodules: advantages, limitations and effect , Mayo Clin Prolc 69 : 44 ~ 49
Hedinger C , 1989 , The WHO histological classification of thyroid tumors: a commentary on the second edition , Cancer 63 : 908 ~ 911
Yamamoto Y , 1990 , Occult papillary carcinoma of the thyroid: a study of 408 autopsy cases , Cancer 65 : 1173 ~ 1179
Ottino A , 1989 , Occult papillary carcinoma at autopsy in La Plara, Argentina , Cancer 64 : 547 ~ 551
Franssila KO , 1986 , Occult papillary carcinoma of the thyroid in children and young adults: a systemic autopsy study in Finland , Cancer 58 : 715 ~ 719
Hedinger C , 1989 , The WHO histological classification of thyroid tumors: a commentary on the second edition , Cancer 63 : 908 ~ 911
Yamamoto Y , 1990 , Occult papillary carcinoma of the thyroid: a study of 408 autopsy cases , Cancer 65 : 1173 ~ 1179
Ottino A , 1989 , Occult papillary carcinoma at autopsy in La Plara, Argentina , Cancer 64 : 547 ~ 551
Franssila KO , 1986 , Occult papillary carcinoma of the thyroid in children and young adults: a systemic autopsy study in Finland , Cancer 58 : 715 ~ 719
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UCI(KEPA) : I410-ECN-0101-2013-514-002674288