다발성 갑상선 유두상암의 임상적 특징

이종길; 이덕규; 이진춘; 이병주; 왕수건; 손석만; 김인주; 김용기

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자료유형: 학술저널

저자정보: 이종길 이덕규 이진춘 이병주 왕수건 손석만 김인주 김용기

저널정보: 대한이비인후과학회 대한이비인후-두경부외과학회지 대한이비인후과학회지 두경부외과학 제52권 제6호

발행연도: 2009.1

수록면: 512 - 515 (4page)

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Background and Objectives：Papillary thyroid cancers (PTCs) often present as multifocal tumors. Whether multifocal tumors are associated with increased risk of recurrence and mortality is still the subject of controversy. The aim of current study was to individualize factors associated with multifocality of papillary thyroid cancer and determine the clinical significance of multifocal thyroid cancer. Subjects and Method：We undertook a retrospective study of 403 patients treated between January, 2003 and June, 2007 for papillary thyroid carcinoma by total thyroidectomy and central compartment neck dissection (n=403) with or without comprehensive lateral neck dissection. There were 342 women and 61 men whose mean age was 47.3 years old. Following criteria were used to study the pattern of and factors related with multifocality：sex, age, extracapsular extension, central compartment lymph node metastasis, the involvement of lateral neck lymph node, AMES risk group, distant metastasis. Results：Of those factors, sex (p=0.0481), central compartment lymph node metastasis (p=0.0007), the involvement of lateral neck lymph node (p=0.0001) were significantly related factors for multifocality of papillary thyroid cancer. Age, primary tumor size, AMES risk group were not significantly related with multifocality. Bilateral or contralateral central compartment lymph node metastasis occurred more frequently in multifocal PTCs (64.0%) than solitary PTCs (46.9)(p=0.012). Conclusion：Our data suggest that the multifocal tumors in patients with papillary thyroid carcinoma are associated with increased risk of bilateral central compartment and lateral cervical lymph node metastasis. Therefore, total thyroidectomy and bilateral central compartment lymph node dissection should be recommended as a routine procedure in multifocal papillary carcinoma.

#갑상선 유두상암·다발성·전이·림프절 #Papillary thyroid cancer·Multifocal·Metastasis·Lymphatic

참고문헌 (12)

참고문헌 신청

Baudin E / 1998 / Microcarcinoma of the thyroid gland: Gustave-Roussy institute experience / Cancer 83 (3) : 553 ~ 559

Carcangiu ML / 1985 / Papillary carcinoma of the thyroid: A clinicopathological study of 241 cases treated at the university of Florence, Italy / Cancer 55 (4) : 805 ~ 828

Chow M / 2003 / Papillary microcarcinoma of the thyroid-prognostic significance of lymph node metastasis and multifocality / Cancer 98 (1) : 31 ~ 40

Iida F / 1969 / Study of intraglandular dissemination of thyroid cancer / Cancer 24 (4) : 764 ~ 771

Kaptan G / 2007 / Incidental papillary microcarcinoma of the thyroid-factors affecting lymph node metastasis / Langenbecks Arch Surg 393 (1) : 25 ~ 29

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