지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.11
- 수록면
- 385 - 391 (7page)
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초록· 키워드
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Purpose: The association between the margin status and the risk of a local recurrence (LR) after breast conservation therapy (BCT) is controversial. In addition, the width of the resection margin that minimizes the risk of LR is unknown. This study examined the interaction between the margin width, tumor characteristics, and adjuvant systemic therapy on the risk of LR after BCT.
Methods: The records of 348 women with T1 and T2 breast cancers, who were treated with BCT between 1997 and 2004, were reviewed. Patients who underwent a re-excision with a positive margin were excluded. The margin was classified as close (≤5 ㎜ tumor-free margin) or negative (＞5㎜ tumor-free margin). Various clinical and pathologic factors were analyzed as potential prognostic factors for LR in addition to the margin width.
Results: The rate of LR for all patients after a mean follow-up of 37.2 months was 3.7% (13/348). The LR rates were significantly associated with young age (＜40 years, P=0.009), high nuclear grade (P=0.032), large tumor size (＞2 ㎝, P=0.021) and negative hormone receptor (P=0.032). A positive axillary lymph node, the presence of EIC, high histological tumor grade, high proliferative index (Ki-67), the presence of lymphovascular invasion, the over-expression of c-erbB2 and the expression of p53 was not significant. Systemic adjuvant therapy was not associated with a lower rate of LR in both groups. The final resection margins were close in 30 patients (8.6%) and negative in 318 patients (91.4%). The rates of LR by the margin width were 6.7% (2/30) for close margins and 3.5% (11/318) for negative margins. There were no significant differences in the rate of LR according to the margin width. The rate of LR in patients with a 1 ㎜ tumor-free margin width was 13.3% (2/15). Moreover, there is a tendency for an increase in the LR with a 1 ㎜ tumor-free margin than with a margin width ＞1 ㎜ (P=0.046).
Conclusion: According to this study, if the margin is tumorfree, a close resection margin (≤5 ㎜) is not associated with an increased rate of LR in BCT. However, a high rate of LR can be expected in patients with 1 ㎜ margins.
Methods: The records of 348 women with T1 and T2 breast cancers, who were treated with BCT between 1997 and 2004, were reviewed. Patients who underwent a re-excision with a positive margin were excluded. The margin was classified as close (≤5 ㎜ tumor-free margin) or negative (＞5㎜ tumor-free margin). Various clinical and pathologic factors were analyzed as potential prognostic factors for LR in addition to the margin width.
Results: The rate of LR for all patients after a mean follow-up of 37.2 months was 3.7% (13/348). The LR rates were significantly associated with young age (＜40 years, P=0.009), high nuclear grade (P=0.032), large tumor size (＞2 ㎝, P=0.021) and negative hormone receptor (P=0.032). A positive axillary lymph node, the presence of EIC, high histological tumor grade, high proliferative index (Ki-67), the presence of lymphovascular invasion, the over-expression of c-erbB2 and the expression of p53 was not significant. Systemic adjuvant therapy was not associated with a lower rate of LR in both groups. The final resection margins were close in 30 patients (8.6%) and negative in 318 patients (91.4%). The rates of LR by the margin width were 6.7% (2/30) for close margins and 3.5% (11/318) for negative margins. There were no significant differences in the rate of LR according to the margin width. The rate of LR in patients with a 1 ㎜ tumor-free margin width was 13.3% (2/15). Moreover, there is a tendency for an increase in the LR with a 1 ㎜ tumor-free margin than with a margin width ＞1 ㎜ (P=0.046).
Conclusion: According to this study, if the margin is tumorfree, a close resection margin (≤5 ㎜) is not associated with an increased rate of LR in BCT. However, a high rate of LR can be expected in patients with 1 ㎜ margins.
목차
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방법
결과
고찰
결론
REFERENCES
참고문헌 (28)
참고문헌 신청
1. [학술지(정기간행물)] - Park CC / 2000 / Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence / J Clin Oncol 18 : 1668 ~ 1675
2. [학술지(정기간행물)] - Cefaro GA / 2006 / Predictors of local recurrence after conservative surgery and whole-breast irradiation / Breast Cancer Res Treat 98 : 329 ~ 335
3. [학술지(정기간행물)] - Mirza NQ / 2002 / Predictors of locoregional recurrence among patients with early-stage breast cancer treated with breast-conserving therapy / Ann Surg Oncol 9 : 256 ~ 265
4. [학술지(정기간행물)] - Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347 : 1227 ~ 1232
5. [학술지(정기간행물)] - Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347 : 1233 ~ 1241
2. [학술지(정기간행물)] - Cefaro GA / 2006 / Predictors of local recurrence after conservative surgery and whole-breast irradiation / Breast Cancer Res Treat 98 : 329 ~ 335
3. [학술지(정기간행물)] - Mirza NQ / 2002 / Predictors of locoregional recurrence among patients with early-stage breast cancer treated with breast-conserving therapy / Ann Surg Oncol 9 : 256 ~ 265
4. [학술지(정기간행물)] - Veronesi U / 2002 / Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer / N Engl J Med 347 : 1227 ~ 1232
5. [학술지(정기간행물)] - Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347 : 1233 ~ 1241
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UCI(KEPA) : I410-ECN-0101-2013-514-002683012