지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.4
- 수록면
- 215 - 220 (6page)
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초록· 키워드
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Purpose: Despite the increasing use of breast-conserving therapy, modified radical mastectomy retains an important primary treatment of breast cancer. The aim of this study was to evaluate the survival of patients with isolated locoregional recurrence (LR) and the prognostic factors for LR after mastectomy.
Methods: We retrospectively analyzed 76 patients who were treated for LR after mastectomy at our hospital between 1987 and 2002. These patients had only isolated LR. The following parameters were analyzed: primary tumor size, primary nodal status, stage, estrogen receptor status, treatment modalities for LR, disease free interval from primary operation and re-recurrence interval.
Results: The median time to develop LR was 18.4 months and the median follow-up period from LR was 19.3 months (range 1.3∼113 months). The 2-year overall survival rate from LR showed 46% and 5-year overall survival rate was 15%. Out of 76 patients, 47 patients (61.8%) developed re-recurrence and the median duration to re-recurrence was 9.6 months. The pattern of re-recurrence showed 45 patients with systemic recurrence and 2 patients with LR. The initial node status (P=0.041), the estrogen receptor status (P=0.009) and re-recurrence interval from LR (P=0.017) were statistically significant factors for survival. The primary tumor size, the stage, the disease free interval, and the treatment modalities for LR were not statistically significant.
Conclusion: The re-recurrence rate after isolated LR in patients with breast cancer showed 61.8% and these patients almost always had systemic recurrence. This study could not show the difference of survival according to the treatment modality for LR but the systemic treatment should be considered for the patients with unfavorable prognostic factors.
Methods: We retrospectively analyzed 76 patients who were treated for LR after mastectomy at our hospital between 1987 and 2002. These patients had only isolated LR. The following parameters were analyzed: primary tumor size, primary nodal status, stage, estrogen receptor status, treatment modalities for LR, disease free interval from primary operation and re-recurrence interval.
Results: The median time to develop LR was 18.4 months and the median follow-up period from LR was 19.3 months (range 1.3∼113 months). The 2-year overall survival rate from LR showed 46% and 5-year overall survival rate was 15%. Out of 76 patients, 47 patients (61.8%) developed re-recurrence and the median duration to re-recurrence was 9.6 months. The pattern of re-recurrence showed 45 patients with systemic recurrence and 2 patients with LR. The initial node status (P=0.041), the estrogen receptor status (P=0.009) and re-recurrence interval from LR (P=0.017) were statistically significant factors for survival. The primary tumor size, the stage, the disease free interval, and the treatment modalities for LR were not statistically significant.
Conclusion: The re-recurrence rate after isolated LR in patients with breast cancer showed 61.8% and these patients almost always had systemic recurrence. This study could not show the difference of survival according to the treatment modality for LR but the systemic treatment should be considered for the patients with unfavorable prognostic factors.
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결론
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Ahn SH / 2006 / Chronological changes of clinical characteristics in 31,115 new breast cancer patients among Koreans during 1996-2004 / Breast Cancer Res Treat 99 : 209 ~ 214
2. [학술지(정기간행물)] - Bedwinek J / 1994 / Natural history and management of isolated local-regional recurrence following mastectomy / Semin Radiat Oncol 4 : 260 ~ 269
3. [학술지(정기간행물)] - Tennvall-Nittby L / 1993 / The total incidence of loco-regional recurrence in a randomized trial of breast cancer TNM stage II. The South Sweden Breast Cancer Trial / Acta Oncol 32 : 641 ~ 646
4. [학술지(정기간행물)] - Karrison TG / 1999 / Dormancy of mammary carcinoma after mastectomy / J Natl Cancer Inst 91 : 80 ~ 85
5. [학술지(정기간행물)] - Carreno G / 2007 / Local recurrence after mastectomy for breast cancer: analysis of clinicopathological, biological and prognostic characteristics / Breast Cancer Res Treat 102 : 61 ~ 73
2. [학술지(정기간행물)] - Bedwinek J / 1994 / Natural history and management of isolated local-regional recurrence following mastectomy / Semin Radiat Oncol 4 : 260 ~ 269
3. [학술지(정기간행물)] - Tennvall-Nittby L / 1993 / The total incidence of loco-regional recurrence in a randomized trial of breast cancer TNM stage II. The South Sweden Breast Cancer Trial / Acta Oncol 32 : 641 ~ 646
4. [학술지(정기간행물)] - Karrison TG / 1999 / Dormancy of mammary carcinoma after mastectomy / J Natl Cancer Inst 91 : 80 ~ 85
5. [학술지(정기간행물)] - Carreno G / 2007 / Local recurrence after mastectomy for breast cancer: analysis of clinicopathological, biological and prognostic characteristics / Breast Cancer Res Treat 102 : 61 ~ 73
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UCI(KEPA) : I410-ECN-0101-2013-514-002687505