지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.11
- 수록면
- 372 - 379 (8page)
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초록· 키워드
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Purpose: Extra-thyroidal extension has been recognized as a poor prognostic factor for increased regional recurrence risk in papillary thyroid carcinoma, and is known to require treatment that is more aggressive. In the recent UICC TNM 6th Classification, an extra-thyroidal extension was divided into a minimal extra-thyroidal extension (T3) and a massive extra-thyroidal extension (T4). The aim of this study was to investigate the clinical effect of a minimal extra-thyroidal extension of a papillary carcinoma for the recurrence of regional cervical lymph nodes.
Methods: We retrospectively studied 154 patients with papillary thyroid carcinoma where a thyroidectomy was performed from Feb. 2003 to May. 2006 at the Department of Surgery, with the exclusion of 6 patients with a massive extra-thyroidal extension. We divided the cases into a no extra-thyroidal extension group and a minimal extra-thyroidal extension group according to the grading of the extra-thyroidal extension. The grading of the extra-thyroidal extension was based on both pathological findings and intraoperative surgical findings. Clinicopathological factors associated with each group were analyzed by univariate and multivariate analysis. We divided the cases into two groups according to age (＜45 yrs, ≥45 yrs) and lymph node status (positive, negative), and compared each group with regards to disease free survival according to the grading of the extra-thyroidal extension.
Results: By univariate analysis, a minimal extra-thyroidal extension was related to lymph node metastasis, tumor size, mutifocality (P＜0.05), and was not related to cervical lymph node recurrence statistically (P=0.108). Cervical lymph node recurrence was related to being male, lymph node metastasis and tumor size (P＜0.05). By multivariate analysis, a minimal extra-thyroidal extension was independently related to tumor size, multifocality, and lymph node metastasis (P＜0.05). In both groups with regards to age and lymph node status, a minimal extra-thyroidal extension was not statistically related to disease free survival (P＞0.05).
Conclusion: We need to downstage to less than T3 for a minimal extra-thyroidal extension because there is no significant difference in disease free survival according to the grading of an extra-thyroidal extension in patients with papillary thyroid carcinoma.
Methods: We retrospectively studied 154 patients with papillary thyroid carcinoma where a thyroidectomy was performed from Feb. 2003 to May. 2006 at the Department of Surgery, with the exclusion of 6 patients with a massive extra-thyroidal extension. We divided the cases into a no extra-thyroidal extension group and a minimal extra-thyroidal extension group according to the grading of the extra-thyroidal extension. The grading of the extra-thyroidal extension was based on both pathological findings and intraoperative surgical findings. Clinicopathological factors associated with each group were analyzed by univariate and multivariate analysis. We divided the cases into two groups according to age (＜45 yrs, ≥45 yrs) and lymph node status (positive, negative), and compared each group with regards to disease free survival according to the grading of the extra-thyroidal extension.
Results: By univariate analysis, a minimal extra-thyroidal extension was related to lymph node metastasis, tumor size, mutifocality (P＜0.05), and was not related to cervical lymph node recurrence statistically (P=0.108). Cervical lymph node recurrence was related to being male, lymph node metastasis and tumor size (P＜0.05). By multivariate analysis, a minimal extra-thyroidal extension was independently related to tumor size, multifocality, and lymph node metastasis (P＜0.05). In both groups with regards to age and lymph node status, a minimal extra-thyroidal extension was not statistically related to disease free survival (P＞0.05).
Conclusion: We need to downstage to less than T3 for a minimal extra-thyroidal extension because there is no significant difference in disease free survival according to the grading of an extra-thyroidal extension in patients with papillary thyroid carcinoma.
목차
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REFERENCES
참고문헌 (22)
참고문헌 신청
1. [학술지(정기간행물)] - Jung YM / 2001 / Recurrence and complications from the surgical procedure for treating a papillary thyroid carcinoma / J Korean Surg Soc 61 : 135 ~ 141
2. [학술지(정기간행물)] - Shaha AR / 2004 / Implications of prognostic factors and risk groups in the management of differentiated thyroid cancer / Laryngoscope 114 : 393 ~ 402
3. [학술지(정기간행물)] - Cady B / 1988 / An expanded view of risk-group definition in differentiated thyroid carcinoma / Surgery 104 : 947 ~ 953
4. [학술지(정기간행물)] - Hay ID / 1990 / Papillary thyroid carcinoma / Endocrinol metab cllin north Am 19 : 545 ~ 576
5. [학술지(정기간행물)] - Hay ID / 1993 / Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort 1779 patients surgically treated at one institution during 1940 through 1989 / Surgery 114 : 1050 ~ 1057
2. [학술지(정기간행물)] - Shaha AR / 2004 / Implications of prognostic factors and risk groups in the management of differentiated thyroid cancer / Laryngoscope 114 : 393 ~ 402
3. [학술지(정기간행물)] - Cady B / 1988 / An expanded view of risk-group definition in differentiated thyroid carcinoma / Surgery 104 : 947 ~ 953
4. [학술지(정기간행물)] - Hay ID / 1990 / Papillary thyroid carcinoma / Endocrinol metab cllin north Am 19 : 545 ~ 576
5. [학술지(정기간행물)] - Hay ID / 1993 / Predicting outcome in papillary thyroid carcinoma: development of a reliable prognostic scoring system in a cohort 1779 patients surgically treated at one institution during 1940 through 1989 / Surgery 114 : 1050 ~ 1057
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UCI(KEPA) : I410-ECN-0101-2013-514-002682999