유두상 갑상선암에서 최소 갑상선외 침범의 예후인자로서의 유용성

이민재; 하태권; 박하경; 이홍태; 신재호; 안민성; 김광희; 배기범; 김태현; 최창수; 김상효

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자료유형: 학술저널

저자정보: 이민재 하태권 박하경 이홍태 신재호 안민성 김광희 배기범 김태현 최창수 김상효

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제12권 제2호

발행연도: 2012.1

수록면: 102 - 106 (5page)

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Purpose: Extrathyroidal extension (ETE) is a risk factor for the recurrence of a papillary thyroid carcinoma (PTC). In the TNM 6th classification system, an extrathyroidal invasion of a differentiated thyroid carcinoma has been classified as T3 (minimal invasion), T4a (extended invasion), and T4b (more extensive unresectable invasion) according to tumor invasion. We investigated the clinicopathologic characteristics, recurrence, and disease-free survival (DFS) of minimal ETE (mETE). Methods: We retrospectively evaluated 332 patients who underwent a thyroidectomy for PTC from January 2005 to December 2006. Results: Of the 332 patients, 103 (31.0%) were found to have a PTC with mETE and 229 (69.0%) patients had a PTC without mETE. In PTC, mETE was related to gender, tumor size, multifocality, Lymph node (LN) metastasis, underlying Hashimoto’s thyroiditis, and surgery. But there is no significant difference in age, recurrence, and LN metastasis between the mETE and No mETE groups. Multivariate analysis demonstrated that LN metastasis (odds ratio=2.273; 95% confidence interval 1.280∼4.037) was recognized as an independent factor for mETE (P=0.005). Disease-free survival was not significantly different between patients with and without mETE (P=0.153). We analyzed the effect of LN metastasis in groups with and without mETE. Based on the presence or absence of LN metastasis, disease-free survival (DFS) rates between each group showed no significant differences. Conclusion: Minimal ETE had no impact on DFS in patients with PTC. Therefore, an appropriate surgical approach and postoperative follow-up are required for tumors with mETE.

#갑상선 유두상암 #최소 갑상선외 침범 #재발 #무병생존 #Papillary thyroid carcinoma #Minimal extra- thyroidal extension #Recurrence #Disease-free survival

참고문헌 (19)

참고문헌 신청

Andersen PE / 1995 / Differentiated carcinoma of the thyroid with extrathyroidal extension / Am J Surg 170 : 467 ~ 470

Arora N / 2008 / Extrathyroidal extension is not all equal: implications of macroscopic versus microscopic extent in papillary thyroid carcinoma / Surgery 144 : 942 ~ 947

Bellantone R / 1998 / Prognostic factors in differentiated thyroid carcinoma: a multivariate analysis of 234 consecutive patients / J Surg Oncol 68 : 237 ~ 241

Ito Y / 2003 / An observation trial without surgical treatment in patients with papillary microcarcinoma of the thyroid / Thyroid 13 : 381 ~ 387

Ito Y / 2006 / Prognostic significance of extrathyroid extension of papillary thyroid carcinoma: massive but not minimal extension affects the relapse-free survival / World J