Correlation between COX-2 Expression and Hormone Receptors in Invasive Ductal Breast Cancer

Jung Ah Lee; Jeoung Won Bae; Sang Uk Woo; Hyunchul Kim; Chul Hwan Kim

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자료유형: 학술저널

저자정보: Jung Ah Lee (고려대학교) Jeoung Won Bae (고려대학교) Sang Uk Woo (고려대학교) Hyunchul Kim (고려대학교) Chul Hwan Kim (고려대학교)

저널정보: 대한외과학회 Annals of Surgical Treatment and Research 대한외과학회지 Vol.78 No.3

발행연도: 2010.3

수록면: 140 - 148 (9page)

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Purpose: COX-2 is known to be elevated in breast cancer, but the clinical relevance is still a matter of debate. The purpose of this study was to determine the prognostic significance and relationship of COX-2 to hormone receptors.
Methods: Between January 2005 and February 2007, 80 specimens from breast cancer patients at Korea University Anam Hospital were reviewed by one pathologist. COX-2 was analyzed as overexpressed if ＞10% of the cells were stained. Clinical characteristics, hormone receptor status, and other prognostic factors were investigated to determine their association with COX-2 expression.
Results: COX-2 was overexpressed in 12 patients (15%). Two patients had locoregional recurrence, eight patients had systemic metastasis, and one patient died. There was no statistically significant correlation between COX-2 expression and age, size, nodal status, histological grade, hormone receptor status, and HER-2/neu positivity. Among tumors that had a positive expression of ER and PR, COX-2 expression was related to larger size (P-value 0.001 and 0.009, respectively) and nodal status (P-value 0.048 and 0.009, respectively). However, there was no statistically significant correlation with tumors that had negative ER or PR expression.
Conclusion: This study suggests that in breast cancer, COX-2 expression has no relationship with clinicopathologic factors; however, a correlation was noted in size and nodal status for ER- and PR-positive tumors. Further prospective study with larger population to clarify the relationship between COX-2 expression and hormone receptor status is necessary.

#Cyclooxygenase 2 #Breast cancer #Estrogen receptor #Progesterone receptor

참고문헌 (27)

참고문헌 신청

1. [학술지(정기간행물)] - Brueggemeier RW / 2005 / Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer / J Steroid Biochem Mol Biol 95 : 129 ~ 136

2. [학술지(정기간행물)] - Brueggemeier RW / 2003 / Aromatase and cyclooxygenases: enzymes in breast cancer / J Steroid Biochem Mol Biol 86 : 501 ~ 507

3. [학술지(정기간행물)] - Diaz-Cruz ES / 2005 / Cyclooxygenase inhibitors suppress aromatase expression and activity in breast cancer cells / J Clin Endocrinol Metab 90 : 2563 ~ 2570

4. [학술지(정기간행물)] - Richards JA / 2002 / Signaling pathways regulating aromatase and cyclooxygenases in normal and malignant breast cells / J Steroid Biochem Mol Biol 80 : 203 ~ 212

5. [학술지(정기간행물)] - Brodie AM / 2001 / Aromatase and COX-2 expression in human breast cancers / J Steroid Biochem Mol Biol 79 : 41 ~ 47

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