지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.6
- 수록면
- 399 - 404 (6page)
이용수
초록· 키워드
오류제보하기
Purpose: Guardix-sol™ is solution type of anti-adhesion barrier, and it is composed of a mixture of hyaluronate (HA) and carboxymethylcellulose (CMC). The anti-adhesive effect was proved through several clinical trials with using this material, but the most efficient viscosity for this solution has not been shown by the previous research. The objective of this study was to evaluate the efficacy and safety of HA/CMC mixture solutions, with varying viscosities, in a rat model.
Methods: Three different viscosities (low=LV, mid=MV and high=HV) of the HA/CMC mixture solutions were prepared to evaluate their potential as a tissue adhesion barrier. The viscosity was measured by a Brookfield viscometer. To evaluate the anti-adhesion effect, a cecal-abdominal wall abrasion model was adopted. The denuded cecum was coated by a HA/CMC mixture of different viscosity or it was left uncoated (the negative control group) and then the denuded cecum was apposed to the abdominal wall (each group: n=10). All the rats underwent a second celiotomy after 14 days to evaluate the extent of their abdominal adhesions and tissue reactions (inflammatory response, granulation tissue formation and toxicity in organs).
Results: The viscosities of the HA/CMC mixture solutions were 248.±24.4 cps in the LV, 1,353.8±4.4 cps in the MV and 3,556.7±38.8 cps in the HV. The grade of adhesion and the adhesion area were significantly lower in the all HA/CMC mixture solution groups compared to the control regardless of their viscosity. The inflammatory responses were not remarkable at the application site and the major solid organs did not show histological change in the experimental groups.
Conclusion: The difference of viscosity of HA/CMC mixture solutions did not affect the efficacy of the adhesion barrier. All the HA/CMC mixture solutions with varying viscosities showed a low inflammatory response and non-toxicity.
Methods: Three different viscosities (low=LV, mid=MV and high=HV) of the HA/CMC mixture solutions were prepared to evaluate their potential as a tissue adhesion barrier. The viscosity was measured by a Brookfield viscometer. To evaluate the anti-adhesion effect, a cecal-abdominal wall abrasion model was adopted. The denuded cecum was coated by a HA/CMC mixture of different viscosity or it was left uncoated (the negative control group) and then the denuded cecum was apposed to the abdominal wall (each group: n=10). All the rats underwent a second celiotomy after 14 days to evaluate the extent of their abdominal adhesions and tissue reactions (inflammatory response, granulation tissue formation and toxicity in organs).
Results: The viscosities of the HA/CMC mixture solutions were 248.±24.4 cps in the LV, 1,353.8±4.4 cps in the MV and 3,556.7±38.8 cps in the HV. The grade of adhesion and the adhesion area were significantly lower in the all HA/CMC mixture solution groups compared to the control regardless of their viscosity. The inflammatory responses were not remarkable at the application site and the major solid organs did not show histological change in the experimental groups.
Conclusion: The difference of viscosity of HA/CMC mixture solutions did not affect the efficacy of the adhesion barrier. All the HA/CMC mixture solutions with varying viscosities showed a low inflammatory response and non-toxicity.
목차
서론
방법
결과
고찰
결론
REFERENCES
참고문헌 (23)
참고문헌 신청
1. [학술지(정기간행물)] - Ray NF / 1993 / Economic impact of hospitalizations for lower abdominal adhesiolysis in the United States in 1988 / Surg Gynecol Obstet 176 : 271 ~ 276
2. [학술지(정기간행물)] - Ray NF / 1998 / Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994 / J Am Coll Surg 186 : 1 ~ 9
3. [학술지(정기간행물)] - Van Der Krabben AA / 2000 / Morbidity and mortality of inadvertent enterotomy during adhesiotomy / Br J Surg 87 : 467 ~ 471
4. [학술지(정기간행물)] - Falk K / 2001 / Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1 / Br J Surg 88 : 286 ~ 289
5. [학술지(정기간행물)] - Burns JW / 1997 / Preclinical evaluation of Seprafilm bioresorbable membrane / Eur J Surg Suppl 577 : 40 ~ 48
2. [학술지(정기간행물)] - Ray NF / 1998 / Abdominal adhesiolysis: inpatient care and expenditures in the United States in 1994 / J Am Coll Surg 186 : 1 ~ 9
3. [학술지(정기간행물)] - Van Der Krabben AA / 2000 / Morbidity and mortality of inadvertent enterotomy during adhesiotomy / Br J Surg 87 : 467 ~ 471
4. [학술지(정기간행물)] - Falk K / 2001 / Reduction of experimental adhesion formation by inhibition of plasminogen activator inhibitor type 1 / Br J Surg 88 : 286 ~ 289
5. [학술지(정기간행물)] - Burns JW / 1997 / Preclinical evaluation of Seprafilm bioresorbable membrane / Eur J Surg Suppl 577 : 40 ~ 48
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UCI(KEPA) : I410-ECN-0101-2013-514-002691192